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Freeze dried ginseng-astragalus powder for injection to strengthen body's resistance and its prepn

A technology of freeze-dried powder injection and Shenqi Fuzheng, which is applied in the field of Shenqi Fuzheng preparation for injection and its preparation, can solve the problems of high impurity content, unqualified clarity, turbidity, etc., and achieve reasonable and reliable preparation process, convenient transportation and The effect of increasing the degree of storage and concentration

Inactive Publication Date: 2006-05-17
南京易川药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the dosage forms for injection are liquid with poor stability. After a certain period of storage, the pH value often changes, causing the appearance to become darker, and even turbid or precipitated, making the clarity unqualified.
At the same time, the content of active ingredients is low and the content of impurities is high, which is not convenient for transportation and storage, and it is not convenient for clinical application in medical care

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Prescription: Codonopsis 2500g, Astragalus 2500g;

[0024] 2. Process: Take the prescription amount of Codonopsis pilosula and Astragalus membranaceus, rinse them with deionized water, add deionized water to soak for 30 minutes, stir and decoct 3 times, the water volume is 8 times, 6 times, 6 times respectively, and the time is 1 hour respectively , 1 hour, 0.5 hour. Combine three extracts, concentrate under reduced pressure to 1.0 g of total medicinal materials per 1 ml, add 95% ethanol under stirring, make the alcohol content reach 70%, refrigerate and stand at 5°C for 24 hours, filter, recover ethanol from the filtrate and reduce Concentrate under pressure to contain 2.0g of total medicinal materials per 1ml, add absolute ethanol under stirring to make the weight of alcohol reach 80%, refrigerate and stand at 5°C for 24 hours, filter, concentrate the filtrate under reduced pressure to dryness, add water for injection to fully Dissolve to make a medicinal solution...

Embodiment 2

[0027] 1. Prescription: Codonopsis 1000g, Astragalus 4000g;

[0028] 2. Process: Take the prescription amount of Codonopsis pilosula and Radix Astragali, rinse them with deionized water, add deionized water to soak for 20 minutes, stir and decoct 3 times, the water volume is 10 times, 8 times, and 8 times respectively, and the time is 1 hour respectively , 1 hour, 0.5 hour. Combine three extracts, concentrate under reduced pressure to 1.2g of total medicinal material per 1ml, add 95% ethanol under stirring, make the alcohol content reach 60%, refrigerate and stand at 5°C for 24 hours, filter, reclaim ethanol from the filtrate and reduce Concentrate under pressure to contain 2.0g of total medicinal materials per 1ml, add absolute ethanol under stirring to make the weight of alcohol reach 80%, refrigerate and stand at 5°C for 24 hours, filter, concentrate the filtrate under reduced pressure to dryness, add water for injection to fully Dissolve to make a medicinal liquid contain...

Embodiment 3

[0031] 1. Prescription: Codonopsis 3000g, Astragalus 2000g;

[0032] 2. Process: Take the prescription amount of Codonopsis pilosula and Radix Astragali, rinse them with deionized water, add deionized water to soak for 40 minutes, stir and decoct 3 times, the water volume is 8 times, 8 times, and 8 times respectively, and the time is 1 hour respectively , 1 hour, 0.5 hour. Combine the three extracts, concentrate under reduced pressure to 1.0 g of total medicinal materials per 1 ml, add 90% ethanol under stirring to make the alcohol content reach 70%, refrigerate and stand at 5°C for 24 hours, filter, recover ethanol from the filtrate and reduce Concentrate under pressure to contain 1.8g of total medicinal materials per 1ml, add absolute ethanol under stirring, make the weight of alcohol reach 80%, refrigerate and stand at 5°C for 24 hours, filter, concentrate the filtrate under reduced pressure to dryness, add water for injection fully Dissolve to make a medicinal solution co...

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PUM

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Abstract

The present invention discloses one kind of freeze dried Dangshen-astragalus powder for injection to strengthen bodyí»s resistance and its preparation process. Dangshen and astragalus are water extracted to obtain water extract; the water extract is concentrated, twice alcohol precipitated, concentrated to dry and dissolved in water; and the water solution is filtered to obtain the effective medicine component; the effective medicine component is added with proper amount of excipient and compounded into solution; and the solution is filtered with hollow fiber membrane, packed and low temperature freeze dried to obtain the freeze dried powder for injection to strengthen bodyí»s resistance. The freeze dried powder is porous, easy to dissolve, high in effective component, stable, convenient in clinical use, high in curative effect and without toxic side effect.

Description

technical field [0001] The invention relates to a Shenqi Fuzheng preparation for injection and a preparation method thereof. Background technique [0002] Shenqi Fuzheng Injection uses Codonopsis pilosula and Astragalus root as the main medicines, and is formulated according to the exquisite theory of TCM syndrome differentiation and treatment. It is a traditional Chinese medicine injection widely used in clinical practice. [0003] Shenqi Fuzheng Injection has a good clinical effect on patients with advanced tumors of Qi deficiency type. It has the functions of nourishing lung and spleen, nourishing Qi and nourishing blood, and can significantly improve the clinical symptoms of patients and patients, and improve the quality of life. Used in conjunction with chemotherapy drugs, it has the effects of synergizing and reducing toxicity, and improving self-immunity. [0004] At present, most of the dosage forms for injection are liquid, with poor stability. After a certain peri...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/19A61K36/344A61P35/00A61P37/04
Inventor 宋建国耿伯显孙福宝温泉
Owner 南京易川药物研究所
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