Heat resistant freeze drying protectant for chicken Newcastle disease live vaccine and its prepn and application

A heat-resistant freeze-drying and Newcastle disease technology, applied in the field of immunology, can solve the problems of inability to realize mass production, inconvenient operation, complicated formula, etc., and achieve the effects of simple formula ingredients and preparation methods, low cost and good heat resistance

Inactive Publication Date: 2006-05-17
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the formula is too complicated and inconvenient to operate, especially because the ingredients of the formula are expensive, which greatly increases the cost of the vaccine and cannot be mass-produced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] [Example 1] Preparation of heat-resistant lyoprotectant of the present invention

[0018] Weigh each component by the following weight: 1.2g of gelatin, 8g of lactose, 1g of arginine, 4g of sorbitol, and dilute to 100ml with distilled water; mix the above components evenly, and steam sterilize to obtain the heat-resistant Lyoprotectant.

Embodiment 2

[0019] [Example 2] Preparation of heat-resistant lyoprotectant of the present invention

[0020] Weigh each component according to the following weight: gelatin 1g, lactose 6g, arginine 0.8g, sorbitol 2g, and distilled water to 100ml; mix the above components evenly, and steam sterilize to obtain the heat-resistant product of the present invention. Lyoprotectant.

Embodiment 3

[0021] [Example 3] Preparation of heat-resistant lyoprotectant of the present invention

[0022] Weigh each component by the following weight: gelatin 1.4g, lactose 10g, arginine 1.2g, sorbitol 6g, be fixed to 100ml with distilled water; The above components are mixed uniformly, and steam sterilized to obtain the resistant product of the present invention. Thermal lyoprotectant.

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PUM

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Abstract

The present invention discloses one kind of heat resistant freeze drying protectant for chicken Newcastle disease live vaccine and its preparation process and application. The heat resistant freeze drying protectant consists of: gelatin 1-1.4 wt%, lactose 6-10 wt%, arginine 0.8-1.2 wt% and sorbic alcohol 2-6 wt%, except distilled water. All the said components are mixed homogeneously and steam sterilized to obtain the heat resistant freeze drying protectant. Experiment shows that the heat resistant freeze drying protectant of the present invention has excellent protection effect on chicken Newcastle disease live vaccine and is superior to available protectants in protecting effect.

Description

technical field [0001] The invention relates to a protective agent for live vaccines, in particular to a heat-resistant freeze-drying protective agent for Newcastle disease live vaccines and a preparation method thereof, belonging to the field of immunology. Background technique [0002] Lyoprotectant and its preparation process are a key technology in the production of live vaccines, which have a great impact on the storage, transportation and use of vaccines. At present, in my country's veterinary vaccines, live freeze-dried vaccines account for a considerable proportion. The commonly used protective agents in China are mainly milk, sucrose, gelatin, etc., with simple formulations and poor protective functions. The freeze-dried vaccines of these traditional protective agents are required to be stored below -15°C, which causes great inconvenience to manufacturers and users, and limits the long-term storage and transportation of finished vaccines. Moreover, improper storage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K39/17A61K47/42A61P31/14
Inventor 孙建宏张弘刘景力隋惠萍魏凤祥金玉亮胡井雷王杰张从禄田枫岚安少敏
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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