Polymorphis of valsartan

A technology for valsartan and tan crystal forms, applied in the field of solid-state chemistry of valsartan, can solve problems such as not describing product characteristics
CN1788004AInactive Publication Date: 2006-06-14TEVA PHARMA IND LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TEVA PHARMA IND LTD
Publication Date
2006-06-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided are crystalline valsartan and amorphous valsartan, and methods for their preparation.
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Description

[0001] priority uncle

[0002] This application claims the benefit of U.S. Provisional Application Serial No. 60 / 473,640, filed May 28, 2003, and U.S. Provisional Application Serial No. 60 / 455,286, filed March 17, 2003, all of which are incorporated herein by reference . field of invention

[0003] The present invention relates to the solid state chemistry of valsartan. Background of the invention

[0004] Valsartan, also known as (S)-N-(1-carboxy-2-methyl-propan-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl) ) biphenyl-4-ylmethyl]-amine having the following structure:

[0005]

[0006] Molecular formula C 24 h 29 N 5 o 3

[0007] Molecular weight 435.52

[0008] Exact mass 435.227040

[0009] Composition C 66.19%H 6.71%N 16.08%O 11.02

[0010] Melting point range 105-110°C

[0011] It is also marketed as the free acid under the trade name DIOVAN. DIOVAN is a prescription drug of valsartan in 40mg, 80mg, 160mg and 320mg dosage oral tablets.

[0012] Valsartan and...

Claims

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