A kind of medicinal composition composed of angelica and chuanxiong and its preparation method

A composition and the technology of Rhizoma Chuanxiong, which are applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as unfavorable extraction of water-soluble active ingredients, unfavorable large-scale production, and easy to cause danger in operation. The effect of low cost, long validity period and high extraction efficiency

Inactive Publication Date: 2012-02-22
SHENYANG PHARMA UNIVERSITY
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AI Technical Summary

Problems solved by technology

The disclosed extraction methods of Angelica and Chuanxiong include ether extraction, ether extraction after ethanol leakage and supercritical extraction, etc. Ether extraction requires a large amount of organic solvents, which is easy to cause environmental pollution, and the operation is easy to be dangerous. The extraction yield of the oily components contained in the two medicines is relatively high, but special equipment is required, and it is not conducive to the extraction of water-soluble active components in the two medicines. Therefore, it is difficult to popularize and apply, and it is not conducive to large-scale production.

Method used

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Embodiment Construction

[0013] 1. Preparation of Total Extract

[0014] a. Grind Angelica sinensis and 30% to 70% Rhizoma Chuanxiong with a weight ratio of 30% to 70% through a 20-mesh sieve, add 8 to 12 times the volume of water, steam distill for 3 to 8 hours, and collect with a volatile oil extractor For the volatile oil, dissolve the oil layer with a small amount of petroleum ether, dissolve in water at 40°C to remove the petroleum ether, and obtain the volatile oil.

[0015] b. Centrifuge the water decoction at 3000rpm for 15min, collect the supernatant and residue, add 8 to 12 times the volume of water to reflux and extract the residue for 0.5 to 4 hours, then centrifuge the water decoction at 3000rpm for 15min, collect the supernatant, and merge twice The supernatant was used to obtain the water-soluble fraction extract.

[0016] c. The water-soluble extract is absorbed by D101 macroporous resin, and the amount of resin is calculated according to 0.5-0.8ml resin / g decoction pieces. The flow ...

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Abstract

The invention relates to a pharmaceutical composition composed of angelica and chuanxiong and a preparation method thereof, which is a pharmaceutical preparation for oral administration prepared from angelica and chuanxiong Chinese medicinal materials or Chinese medicinal slices. The technical solutions of the present invention include: first, using Angelica sinensis and Rhizoma Chuanxiong as raw materials, steam distillation to collect the volatile oils of Angelica sinensis and Rhizoma Chuanxiong, then decocting with water, absorbing with macroporous resin and spray drying to prepare water-soluble extract powder, combining the volatile oil and water-soluble Extract powder to obtain the total extract. Second, the total extract is used as a medicinal raw material, and certain pharmaceutical auxiliary materials are used to prepare soft capsules or dripping pills of pharmaceutical preparations for oral administration. The invention has high extraction efficiency, low ointment yield, and relatively comprehensively retains the active ingredients in the original bergamot powder.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicines. Specifically, the invention relates to a compound traditional Chinese medicine for promoting blood circulation and removing blood stasis-a pharmaceutical composition composed of total extracts of angelica and chuanxiong and a preparation method thereof. Background technique: [0002] The prescription of Angelica and Chuanxiong is called "bergamot powder", which comes from "Puji Benshifang", which is a medicine for nourishing and promoting blood circulation. The name of the prescription is Bergamot powder, because although the prescription has two flavors, it nourishes blood and activates blood, promotes blood and qi, and treats prenatal and postpartum dizziness, headache, dystocia and hemorrhage, and fetal death. Bergamot, hence the name. Modern Chinese medicine classifies this prescription as a drug pair for promoting blood circulation, removing blood stasis, stopping ble...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/232A61K9/20A61P15/00
Inventor 崔福德冯丽莉胡杰
Owner SHENYANG PHARMA UNIVERSITY
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