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Small volume vincamine injection and its prepn process

A technology for vinpocetine and injections, applied in the formulation and preparation process of small-capacity vinpocetine injections, which can solve problems such as secondary pollution, affecting drug concentration and ease of use, and poor bioavailability of oral preparations

Active Publication Date: 2007-11-07
HENAN RUNHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Vinpocetine was first successfully developed by Gedeon Richter Company in Hungary. The chemical synthesis process has been disclosed. From raw materials to preparation of drugs, the bioavailability of oral preparations is poor, and the freeze-dried powder needs to be dissolved twice, which affects the concentration of the drug and the convenience of use. Possibility of secondary pollution

Method used

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Examples

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Embodiment Construction

[0026] The present invention is further illustrated by the following examples, but the present invention is not limited thereto.

[0027] Example 1

[0028] Add 2 / 3 of the prepared water to the preparation tank, take the weighed co-solvent and vinpocetine and add them to the preparation tank in turn to completely dissolve the vinpocetine, then add the weighed antioxidant, physical Stabilizer and blood vessel regulating stimulant are dissolved completely, supplemented with nearly full amount of water for injection, adjusted pH value to 2.8-3.6 with pH regulator, stirred for 30 minutes after cooling, added 0.03% medicinal charcoal for 15-20 minutes to absorb , filtered and canned to get the finished product.

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PUM

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Abstract

The present invention discloses one kind of small volume vincamine injection and its preparation process. The small volume vincamine injection consists of vincamine as main medicine component 3-20 weight portions and supplementary material including co-solvent 0.1-1 weight portions, antioxidant 0.5-10 weight portions, physical stabilizer 50-100 weight portions, and blood stimulation regulator 0.5-10 weight portions. It has high stability, long validity period, high bioavailability, capacity of being used directly and other advantages.

Description

technical field [0001] The invention relates to an injection containing vinpocetine and a preparation method thereof, in particular to a formula and a preparation process of a small-capacity vinpocetine injection. Background technique [0002] Vinpocetine is a drug extracted from the natural plant periwinkle and then chemically synthesized. It is a representative phosphodiesterase inhibitor. It is highly fat-soluble and insoluble in water. It can selectively expand brain blood vessels, Actively improve glucose metabolism, protect neurons and other pharmacological effects, for the treatment of ischemic cerebrovascular disease, stroke sequelae, dementia, etc., also have a good therapeutic effect on circulatory eye diseases and ear diseases; Vinpocetine is also a A good reagent for studying the effects of phosphodiesterase inhibitors. [0003] Vinpocetine was first successfully developed by Gedeon Richter Company in Hungary. The chemical synthesis process has been disclosed. F...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4375A61P9/10A61P25/00
Inventor 王惠彬李莉
Owner HENAN RUNHONG PHARMA
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