Oil-in-oil nonaqueous microemulsion used as medicine carrier and its medicine prepn

Abstract

The present invention discloses oil-in-oil nonaqueous microemulsion used as medicine carrier and its medicine preparation. The oil-in-oil nonaqueous microemulsion consists of oil phase I, oil phase II, surfactant and co-surfactant, and can dissolve water insoluble medicines to prepare microemulsion. The nonaqueous microemulsion has the advantages of no hydrolysis and long effective period, slow or controlled release of medicine, nanometer level dispersion of water insoluble medicine and obviously raised bioavailability. For example, the present invention can obtain bioavailability of puerarin microemulsion and puerarin sol as high as 40.41 % and 52.68 % separately.

Description

Technical field [0001] The present invention belongs to a pharmaceutical preparation carrier, in particular a medicinal oil-in-oil type non-aqueous microemulsion used as a pharmaceutical carrier. It can be used as a solvent or carrier for one or more drugs or active ingredients, and thus Prepared into nano-dispersed pharmaceutical preparations. Background technique [0002] Microemulsion is composed of two (or more than two) immiscible liquids. Under the action of amphiphilic compounds, it forms a liquid-liquid dispersion system that is transparent or translucent, isotropic, and thermodynamically stable. The microemulsion in the general sense is an aqueous microemulsion, which is generally composed of water, oil, surfactant and co-surfactant. Microemulsion is a kind of nano-dispersed system, and its particle size is between 10-100nm. In the pharmaceutical industry, microemulsion preparations can improve the solubility of poorly soluble drugs in water, improve the bioavailability ...

AI Technical Summary

Problems solved by technology

At present, there are some research reports on the chemical industry of non-aqueous microemulsions, but the formulations used are not pharmaceutical excipients and are highly toxic

[0004] It should be noted that the non-aqueous microemulsion of the present invention is different from existing drug carriers such as self-microemulsion, microemulsion composition or microemulsion pre-concentrate, and they have at least two problems: (1) contain a higher Surfactant, especially self-microemulsion, the amount of its surfactant is higher than 30% usually; Difficult to determine, and the particle size and particle size distribution are important quality indicators of the microemulsion system

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