Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation and technique of ondansetron hydrochloride oral liquor

A technology of ondansetron hydrochloride and oral solution, which is applied in liquid delivery, emulsion delivery, digestive system, etc., and can solve problems such as difficulty in taking medicine and increasing pain of patients

Inactive Publication Date: 2006-09-20
YIKANGXING PHARMA BEIJING
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Clinically applied injections are mainly used for the prevention of radiotherapy and chemotherapy and the prevention of nausea and vomiting during treatment, which are suitable for inpatients. The oral dosage form is only ondansetron hydrochloride tablets, which are mainly used for consolidation and outpatients. The patient has a foreign body sensation when taking the tablet, causing nausea and vomiting, which makes it difficult to take the medicine and easily increases the pain of the patient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Accurately weigh 5 g of ondansetron hydrochloride, 50 g of citric acid, 6.25 g of sodium citrate, 1000 g of sorbitol, 5 g of stevioside, and 10 g of sodium benzoate into a container, add an appropriate amount of distilled water, and stir until completely dissolved. Add water to 5000ml, and quantitatively dispense 5ml per bottle. The finished product after potting is sterilized by circulating steam at 100°C for 15 minutes, and all indicators are qualified through quality inspection. This medicinal solution is a colorless clear solution.

Embodiment 2

[0011] Accurately weigh 100 mg of ondansetron hydrochloride, 10 g of citric acid, 0.3 g of sodium citrate, 1 g of sorbitol, 0.06 g of stevioside, and 0.2 g of sodium benzoate into a container, add an appropriate amount of distilled water, and stir until completely dissolved. Add water to 100ml, quantitatively dispense 5ml per bottle. The finished product after potting is sterilized by circulating steam at 100°C for 15 minutes, and all indicators are qualified through quality inspection. This medicinal solution is a colorless clear solution.

Embodiment 3

[0013] Accurately weigh 100 mg of ondansetron hydrochloride, 0.5 g of citric acid, 1 g of sodium citrate, 3.5 g of sorbitol, 0.06 g of stevioside, and 0.2 g of sodium benzoate into a container, add an appropriate amount of distilled water, and stir until completely dissolved . Add water to 100ml, quantitatively dispense 5ml per bottle. The finished product after potting is sterilized by circulating steam at 100°C for 15 minutes, and all indicators are qualified through quality inspection. This medicinal solution is a colorless clear solution.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An oral liquid of ondansetron hydrochloride is prepared from ondansetron hydrochloride, citric acid, sodium citrate, sorbitol, rebaudioside and sodium benzoate through proportional mixing, dissolving in distilled water, stirring, filtering, loading in bottles, and sterilizing.

Description

technical field [0001] The invention relates to a dosage form and a preparation method of ondansetron hydrochloride oral solution, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Ondansetron Hydrochloride Injection and Tablets have been included in the National Essential Drugs List (A0146) and the National Medical Insurance Drug List, and are the first-line drugs for the clinical treatment of nausea and vomiting caused by tumor chemotherapy and radiotherapy. [0003] Clinically applied injections are mainly used for the prevention of radiotherapy and chemotherapy and the prevention of nausea and vomiting during treatment, which are suitable for inpatients. The oral dosage form is only ondansetron hydrochloride tablets, which are mainly used for consolidation and outpatients. The foreign body sensation caused by the patient's nausea and vomiting when taking the tablet makes it difficult to take the medicine and easily increases t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61K9/08A61K9/10A61P1/08
Inventor 王峰
Owner YIKANGXING PHARMA BEIJING