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Astragaloside injection and preparation method thereof

A glycoside injection, the technology of total astragalosides, applied in the field of total astragaloside injections, can solve the problems of increasing side effects and increasing side effects of intravenous infusion, and achieve the effects of controllable quality, good clarity and high stability

Active Publication Date: 2006-10-04
CHENGDU DIAO JIUHONG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The addition of co-solvents and co-diluents to injections will increase the risk of side effects, especially the risk of side effects in intravenous infusion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation method of total astragaloside injection 1 of the present invention:

[0040]Astragalus medicinal material conforms to the relevant regulations under the item of Astragalus membranaceus on page 249 of the first part of the Chinese Pharmacopoeia in 2000, and astragaloside IV in the medicinal material of Astragalus membranaceus was detected by high performance liquid chromatography, and the medicinal material of Astragalus membranaceus contained astragaloside IV (C 41 h 68 o 14 ) shall not be less than 0.06%.

[0041] Take 500 kg of astragalus decoction pieces (2-4mm thick slices, produced in Inner Mongolia), add 8 times the amount of water and decoct three times, 1.5 hours each time, combine the decoction liquid, filter, and concentrate the filtrate under reduced pressure (temperature: 70°C; vacuum degree: -0.08Mpa) to a relative density of 1.15 (measured at 60°C), precipitate with 95% ethanol until the alcohol content reaches 80%, refrigerate and ...

Embodiment 2

[0043] Embodiment 2 The preparation method of total astragaloside injection 2 of the present invention:

[0044] Take 500 kg of astragalus decoction pieces (2-4mm thick slices, produced in Shaanxi Province), add 12 times the amount of water to decoct twice, each time for 2 hours, combine the decoction liquid, filter, and concentrate the filtrate under reduced pressure (temperature: 70°C; vacuum Degree: -0.08Mpa) to a relative density of 1.25 (measured at 60°C), precipitate with 95% ethanol until the alcohol content reaches 90%, refrigerate and stand for 27 hours, filter, take the filtrate to recover ethanol and concentrate to the equivalent of 0.75 grams of crude drug, refrigerated for 36 hours, filtered. Take the filtrate and pass it through the HPD700 macroporous adsorption resin column, wash it with water until it is nearly colorless, elute it with 80% ethanol, collect the eluate, filter it, recover the ethanol and concentrate it to a relative density of 1.15 (measured at 6...

Embodiment 3

[0046] Example 3 The preparation method of total astragaloside injection 3 of the present invention:

[0047] Take 500 kg of astragalus decoction pieces (2-4mm thick slices, produced in Shanxi Province), add 8 times the amount of water and decoct three times, 1.5 hours each time, combine the decoction liquid, filter, and concentrate the filtrate under reduced pressure (temperature: 70 ° C; vacuum degree : -0.08Mpa) to a relative density of 1.25 (measured at 60°C), precipitate with 95% ethanol until the alcohol content reaches 65%, refrigerate and stand for 27 hours, filter, take the filtrate to recover ethanol and concentrate to 0.75 per milliliter gram of crude drug, refrigerated and allowed to stand for 24 hours, filtered. Take the filtrate and pass it through the LD140 macroporous adsorption resin column, wash with water until it is nearly colorless, elute with 75% ethanol, collect the eluate, filter, recover the ethanol and concentrate to a relative density of 1.20 (measur...

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Abstract

The invention relates to an injection using astragalus root glycosides extract as the active ingredient, which also comprises pharmaceutically acceptable adjunct for injection, the content of the astragalus root glycosides in the total astragalus root extract is 80-100%, each unit of the preparation contains astragalus root glycosides 90-300mg.

Description

technical field [0001] The invention relates to an injection of total astragalosides, in particular, an injection prepared with total astragalosides as an active ingredient and a preparation method thereof, belonging to the field of medicines. Background technique [0002] Viral myocarditis is one of the common heart diseases in clinical practice. Its incidence rate has shown a clear upward trend in the past ten years, with an increase of nearly 10 times. It often leaves sequelae of different degrees (such as arrhythmia and cardiac insufficiency), which seriously endangers human health. Currently there is no specific drug. Therefore, it is extremely important and necessary to develop and research new drugs for viral myocarditis. Modern medicine believes that its cause is caused by a variety of viral infections, and the vast majority of viral myocarditis is caused by Coxsackie virus and ECHO virus clinically. For viral myocarditis, drugs that promote myocardial metabolism a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K31/7048A61P9/04A61P9/00A61P31/12
Inventor 刘忠荣付铁军及元乔庞红何民黄瑜李伯刚
Owner CHENGDU DIAO JIUHONG PHARMA FAB
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