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Method for preparing traditional Chinese herbs or natural product extract to make component stable

A technology of natural products and extracts, applied in the field of blending, can solve the problems of sample representativeness, unstable uniformity, low cost of materials, and large dosage.

Inactive Publication Date: 2010-05-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to ensure the stable and uniform internal quality of Chinese medicinal materials and natural product extracts, people have proposed a method of blending traditional Chinese medicine and natural product raw materials first and then extracting them. The main disadvantage of this raw material blending method is that the representativeness and uniformity of the samples are not enough when sampling and analyzing raw materials. Stable, after blending, the difference between the theoretical value and the actual value of the index component content of the extract is larger than that of the extract blending method
[0005] In order to ensure that the internal quality of Chinese medicinal materials and natural product extracts is stable and uniform, people have proposed a method for blending Chinese medicinal materials and natural product extracts, such as the patent application with the publication number CN1586509A. This method has the following disadvantages: there is only one objective function for optimization , using the absolute value error form for the relative deviation of the index component content and requiring the upper and lower errors to be equal, which cannot provide flexible and diverse choices for users; it does not provide the lowest cost of materials used while meeting the requirements of the content of the index components after the extract is blended. One batch Practical optimization goals such as the maximum amount of extract; there is no method to limit the amount of extract (that is, the blending ratio) when blending, and it is not possible to specify the minimum and maximum proportions of certain batches of extracts; the optimization model of this method only It can control the theoretical content of the index components of the extract blending product. Because the actual blending operation will introduce errors, the difference between the theoretical content and the actual content is very likely to cause the theoretical content to be qualified but the actual content to be unqualified. However, this invention does not provide a corresponding solution mechanism.

Method used

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  • Method for preparing traditional Chinese herbs or natural product extract to make component stable
  • Method for preparing traditional Chinese herbs or natural product extract to make component stable
  • Method for preparing traditional Chinese herbs or natural product extract to make component stable

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] Embodiment 1: Using the method of the present invention to blend the salvia miltiorrhiza extract and ensure that the content of the index components of the blended product is stable

[0137] Salvia miltiorrhiza is the main raw material of Danshen injection water injection and powder injection, and also an important raw material of other injections such as Xiangdan injection. In this example, salvianolic acid B, danshensu, and protocatechualdehyde are listed as index components that need to be controlled in content. A total of 58 batches of wild and cultivated Danshen medicinal materials were collected and purchased nationwide, including 14 wild batches and 44 planted batches. The medicinal materials were identified by the Institute of Traditional Chinese Medicine and Natural Products.

[0138] The goal of setting this embodiment is to investigate whether the extract blending method of the present invention can ensure that the index component content Cm of the extract bl...

Embodiment 2

[0282] Embodiment 2: Adopt the method of the present invention to blend the salvia miltiorrhiza extract and ensure that the index component content of the blended product is stable

[0283] In order to fully reflect the application effect of the present invention, the purpose of setting this example is to illustrate the application mode in which the present invention can impose mandatory requirements on the amount of extracts and allow different upper and lower limit deviations of component content in the constraint conditions.

[0284] The symbols in this embodiment have the same meanings as those in Embodiment 1. Step 1 of this embodiment is the same as that of Embodiment 1, that is, Cs=(3.63 0.49 0.074) T . Step 2 of this embodiment sets c l =(0.08 0.10 0.16) T , c u =(0.20 0.10 0.08) T , at this time the allowable ranges of the contents of the three components are different; the similarity constraint is not considered. Step 3 of this embodiment is the same as that of...

Embodiment 3

[0288] Embodiment 3: Using the method of the present invention to blend the salvia miltiorrhiza extract and ensure that the content of the index components of the blended product is stable

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PUM

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Abstract

The present invention relates to a method for blending Chinese medicinal material or natural product extract to make its component content be stable. Said method includes the following steps: 1), defining target component and its content of Chinese medicinal material or natural product standard extract; 2), defining the parameters of relative deviation range, etc. of its target component content when the Chinese medicinal material extract blend quality is acceptable; 3), determining target component content of every batch of extract to be blended; 4), defining blending parameter, quality control parameter and blending target function of extract so as to form constrained optimization problem; 5), resolving constrained optimization probtem so as to obtain optimum extract blending ratio; and6), mixing every batch of extract according to said optimum blending ratio so as to obtain the blend whose target component content is acceptable. Said invention can be extensively used in productionprocess of Chinese medicine, natural product, biological product, wine, beverage, health-care product, flavouring product, edible oil, fuel oil, gas and feed, etc.

Description

technical field [0001] The invention relates to a blending method, in particular to a method for blending Chinese medicinal materials or natural product extracts to stabilize component content. Background technique [0002] Chinese medicinal materials and natural products are important sources of food, health care products, medicines, spices and chemical raw materials. China's diverse natural conditions have bred rich resources of Chinese medicinal materials and natural products. According to the statistics of "Chinese Traditional Medicine and Natural Product Resources", my country has 11,146 kinds of medicinal plants, 1,581 kinds of medicinal animals, and 80 kinds of medicinal minerals, of which more than 600 kinds are commonly used Chinese medicinal materials and natural products. Chinese herbal medicines and natural products mainly have two growth methods: artificial cultivation and wild. There are more than 200 cultivated varieties of commonly used Chinese herbal medici...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00
Inventor 罗国安杨辉华刘永锁梁琼麟王义明
Owner TSINGHUA UNIV