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Suspension spray for treating allergic rhinitis and its preparing method

A technology of allergic rhinitis and spray, which is applied in the field of medicine, can solve problems such as environmental pollution and large investment in production equipment, and achieve the effects of cost reduction, convenient operation and simple process

Inactive Publication Date: 2006-11-08
XIUZHENG PHARMA GROUP HOIDING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Beclomethasone dipropionate is the medicine for the treatment of allergic rhinitis, and its preparation on the market is an aerosol, and the aerosol has the following disadvantages: the aerosol needs a pressure-resistant container, and its production equipment investment is relatively large; in addition, the aerosol The propellant used in the aerosol is Freon, which can pollute the environment, so the application of the aerosol has certain limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take: Beclomethasone dipropionate 0.1g,

[0019] Ethanol 5.0g,

[0020] Purified water 995g spare;

[0021] Preparation Process:

[0022] 1. Dissolve beclomethasone dipropionate in 90% (V / V) ethanol to make the drug into an ethanol solution for subsequent use;

[0023] 2. Stir the purified water at a high speed (5000 rpm) in a homogenizer, and add the ethanol solution in step 1 to it, so that the drug is recrystallized into tiny crystals in the suspension solvent to achieve the purpose of suspension;

[0024] 3. After adding the ethanol solution in step 1, continue to stir at the same stirring speed for 1 minute;

[0025] 4. After stopping the stirring, let stand to defoam, and obtain the present invention after constant volume.

Embodiment 2

[0027] Take: Beclomethasone dipropionate 0.15g,

[0028] Ethanol 10.0g,

[0029] Purified water 990g spare;

[0030] Preparation Process:

[0031] 1. Beclomethasone dipropionate is dissolved in 95% (V / V) ethanol to make the drug into an ethanol solution for subsequent use;

[0032] 2. Stir the purified water at a high speed (9000 rpm) in a homogenizer, and add the ethanol solution in step 1 to it to recrystallize the drug into tiny crystals in the suspension solvent to achieve the purpose of suspension;

[0033] 3. After adding the ethanol solution in step 1, continue to stir at the same stirring speed for 3 minutes;

[0034] 4. After stopping the stirring, let stand to defoam, and obtain the present invention after constant volume.

Embodiment 3

[0036] Take: Beclomethasone dipropionate 0.2g,

[0037] Ethanol 20.0g,

[0038] Purified water 980g spare;

[0039] Preparation Process:

[0040] 1. Dissolve beclomethasone dipropionate in absolute ethanol to make the drug into an ethanol solution for subsequent use;

[0041] 2. Stir the purified water at a high speed (12000 rpm) in a homogenizer, and add the ethanol solution in step 1 to it to recrystallize the drug into tiny crystals in the suspension solvent to achieve the purpose of suspension;

[0042] 3. After adding the ethanol solution in step 1, continue to stir at the same stirring speed for 5 minutes;

[0043] 4. After stopping the stirring, let stand to defoam, and obtain the present invention after constant volume.

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PUM

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Abstract

The present invention relates to medicine technology, and especially suspension spray for treating allergic rhinitis and its preparation process. The preparation process of the spray includes the following steps: dissolving beclometasone propionate in ethanol solution or ethanol to form ethanol solution; adding the ethanol solution of beclometasone propionate into pure water under high speed stirring for the medicine to re-crystallize into micro crystal and to form the suspensoid; further stirring for 1-5 min; stilling to eliminate bubble and packing in certain volume. The technological process is simple, low in cost and environment friendly.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing a suspension. The international patent classification numbers are: A61K51 / 12, A61P11 / 02. Background technique [0002] Beclomethasone dipropionate is the medicine for the treatment of allergic rhinitis, and its preparation on the market is an aerosol, and the aerosol has the following disadvantages: the aerosol needs a pressure-resistant container, and its production equipment investment is relatively large; in addition, the aerosol The propellant used in the aerosol is Freon, which can pollute the environment, so the application of the aerosol has certain limitations. Contents of the invention [0003] The object of the present invention is to provide a suspension type spray for treating allergic rhinitis with low cost, simple method, convenient operation, good suspension effect and no pollution to the environment and its preparation method....

Claims

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Application Information

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IPC IPC(8): A61K31/567A61K9/10A61K9/12A61P11/02A61P37/08
Inventor 张显涛高陆白冰王鑫
Owner XIUZHENG PHARMA GROUP HOIDING
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