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Composite biomaterials for bone implants

A technology of composite biomaterials and bone implants, applied in bone implants, joint implants, joint implants, etc., can solve problems such as uneconomical

Inactive Publication Date: 2006-11-15
CENT NACIONALDE INVESTIGACIONES CIENTIFICAS CNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] On the other hand, many existing biomaterials for bone implants are not economically viable for large populations

Method used

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  • Composite biomaterials for bone implants
  • Composite biomaterials for bone implants
  • Composite biomaterials for bone implants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A homogeneous mixture of calcium salts having an average particle size of 0.1 mm, (Table 1) of the approximate composition indicated in No. 10, is gradually moistened with POVIAC solution (25%) in acetone until a paste is obtained. The mixture was sieved to obtain granules with a diameter between 1 and 2 mm, which were left to dry at room temperature. The dried granules were pulverized in a commiseration mill, the powder obtained was wetted again with acetone, sieved and dried to obtain granulated compacts with an average particle size from 1 to 2 mm.

[0022] Thus, the obtained product with a polymer content of about 20% is suitable as a bone implant material for filling cavities in bone such as sequelae of tumors and cysts.

Embodiment 2

[0024] Acetylsalicylic acid was added to the inorganic salt mixture described in the previous examples, followed by proper mixing to obtain a homogeneous mass, which was carried out in the same manner to obtain granules with 15% POVIAC1 and 2.5% ASA. This "composite" acts as a system for controlled drug delivery (figure 1 ).

Embodiment 3

[0026] A portion of porous hydroxyapatite HAP-200 with a particle size between 2 and 2.5 mm and similar composition to Mixture 2 (González R.; Melo M.C.; Pérez A.; Rodríguez B.C. Coral-like structured porous hydroxyapatite HAP -200. Main physicochemical properties. Quimica Nova, 16 (6) November-December: 509-512; 1993) The particles were immersed in a 25% acetone suspension of POVIAC and stirred (Table 1) 10% with 0.1mm Particle size No. 5 mixture for 10 minutes. The particles were separated and air dried. The product obtained in this way maintains its original porous structure with polymer layer plugging in the entire surface ( figure 2 ).

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Abstract

The invention relates to bone implant biomaterials comprising an inorganic phase which is formed by calcium salts, mainly by phosphates and hydroxy- and carbonate-apatites, and an organic phase containing polymers derived from vinyl acetate and crotonic acid. The inventive biomaterials, which can be dense or porous, have different reabsorption speeds when used as implants in living tissue depending on the type and proportion of the constituent phases thereof. Said biomaterials can also be used as supports in the production of systems for the controlled release of pharmaceuticals.

Description

technical field [0001] The present invention has application in the field of synthesis and application of biomaterials, in particular known as synthetic or hybrid biomaterials (composites), or other biomedical applications as drug carriers, controllable drug delivery systems, in this case, Formed from calcium carbonate monophosphate ceramic and vinyl acetate derived polymers, the biomaterial can serve as a replacement for hard tissue when it is damaged or lost. Background technique [0002] The need to replace, reconstruct and / or regenerate damaged or lost bone tissue in different parts of the human body has been a challenge with more or less success since the beginning of man for centuries. Although one of the first solutions found was the use of different types of bone grafts, today they are are being replaced by other biological materials. A long list of materials can be prepared for these purposes, including different types of metals, polymers, ceramics, and glasses, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61F2/00A61F2/02A61F2/28A61F2/30A61L27/42A61L27/46
CPCA61F2/28A61F2002/30032A61F2002/30062A61F2002/30677A61F2210/0004A61F2250/003A61F2310/00293A61L27/425A61L27/46A61L2430/02
Inventor 雷蒙·冈萨雷兹·圣图斯阿尔伯特·格勒莫·苏萨特·派兹
Owner CENT NACIONALDE INVESTIGACIONES CIENTIFICAS CNIC
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