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Prophylaxis and/or treatment of portal hypertension

A portal hypertension and inhibitor technology, which can be applied to peptide/protein components, medical preparations containing active ingredients, antibacterial drugs, etc., and can solve problems such as unsatisfactory treatment or prevention of diseases or medical complications.

Inactive Publication Date: 2006-11-29
弗赖堡大学综合诊所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bleeding complications of the portal vein or a number of other conditions or medical complications have not been satisfactorily treated or prevented to date

Method used

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  • Prophylaxis and/or treatment of portal hypertension
  • Prophylaxis and/or treatment of portal hypertension
  • Prophylaxis and/or treatment of portal hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0120] According to the studies described in Example Series 2, oral administration of vardenafil produced an effect in two patients whose etiology was cirrhosis with pathological parallel or circuitous circulation. In this regard, before and after a single oral administration of vardenafil 10 mg, Doppler sonographic imaging detected the flow in the devious circulation of the portal venous system: a patient's gastric coronary vein (V. coronaria ventriculi) and esophageal varices, Another examination of the patient's reopened umbilical vein (V. umbilicalis). The results confirmed that the total flow in the portal vein increased, while the flow in the gastric coronary or umbilical vein decreased by about 30%.

[0121] This result suggests a very beneficial effect that, by increasing portal venous blood flow with unchanged arterial flow, portal venous pressure can be lowered and detoured circulation can be inhibited. By reducing detour flow, the risk of variceal bleeding and comp...

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PUM

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Abstract

The invention relates to a medicament for the prophylaxis and / or treatment of diseases or complications associated with portal hypertension, especially haemorrhagic complications.

Description

technical field [0001] The present invention relates to a novel drug therapy for the prevention and / or treatment of portal hypertension (high pressure in the area of ​​the portal vein) and diseases or medical complications closely related thereto. Background technique [0002] Portal hypertension (portal hypertension is high pressure in the area of ​​the portal vein) especially the cause of terrible bleeding from the upper gastrointestinal tract. The most common is bleeding from "esophageal varices", that is, varices that develop inside the esophagus because blood flow through the liver is obstructed and blood seeks "detour routes". Another difficult complication of portal hypertension is bleeding from gastric varices. In addition, other serious or life-threatening complications of portal hypertension (hepatic encephalopathy due to reduced blood flow to the liver, hepatorenal syndrome, hepatopulmonary syndrome, ascites, spontaneous bacterial peritonitis, metabolic disturban...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K31/00A61K38/095A61K45/06A61P9/12
CPCA61K45/06A61K38/31A61K31/00A61K31/519A61K31/4985A61P1/16A61P11/00A61P31/04A61P43/00A61P9/00A61P9/12A61P9/14A61K2300/00
Inventor W·克莱塞尔
Owner 弗赖堡大学综合诊所
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