Prophylaxis and/or treatment of portal hypertension
A portal hypertension, drug technology, applied in the direction of peptide/protein components, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as diseases or medical complications that cannot be satisfactorily treated or prevented.
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[0121] According to the studies described in Example Series 2, oral administration of vardenafil produced an effect in two patients whose etiology was cirrhosis with pathological parallel or circuitous circulation. In this regard, before and after a single oral administration of vardenafil 10 mg, Doppler sonographic imaging detected the flow in the devious circulation of the portal venous system: a patient's gastric coronary vein (V. coronaria ventriculi) and esophageal varices, Another examination of the patient's reopened umbilical vein (V. umbilicalis). The results confirmed that the total flow in the portal vein increased, while the flow in the gastric coronary or umbilical vein decreased by about 30%.
[0122]This result suggests a very beneficial effect that, by increasing portal venous blood flow with unchanged arterial flow, portal venous pressure can be lowered and detoured circulation can be inhibited. By reducing detour flow, the risk of variceal bleeding and compl...
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