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Method and composition for treatment or prophylaxis of amyloidosis disorders

A technology of amyloidosis and composition, which is applied in the direction of drug combination, active ingredient of heterocyclic compound, drug delivery, etc., and can solve problems such as no systemic pathological characteristics

Inactive Publication Date: 2006-12-20
ACRUX DDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the exception of the SMON case in Japan, no systemic pathological features have been reported in the open literature due to the administration of clioquinol

Method used

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  • Method and composition for treatment or prophylaxis of amyloidosis disorders
  • Method and composition for treatment or prophylaxis of amyloidosis disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Enhancement of transdermal properties of 1,10-phenanthroline by use of octyl salicylate in a transdermal spray composition.

[0071] components

quantity

1,10-Phenanthroline

-

Aqueous ethanol (95

%(v / v)(volume ratio))

5% w / v (weight

Volume ratio)

-

to 100mL

components

quantity

1,10-Phenanthroline

Octyl Salicylate

Aqueous ethanol

(95%v / v)

5%w / v

5%w / v

to 100mL

[0072] Such as figure 1 As shown, the addition of a safe sunscreen ester transdermal enhancer octisalate significantly increased the transdermal delivery of 1,10-phenanthroline through the skin by 1.3 times (p<0.01).

[0073] Diffusion experiments were performed using excised human epidermis as a model membrane. These experiments were carried out over a period of 24 hours using a stainless steel flow-through diffusion cell based on the aforementioned litera...

Embodiment 2

[0076] Acceleration of estradiol transdermality by using other safe sunscreen ester type transdermal enhancers in transdermal spray compositions.

[0077] components

quantity

Estradiol

-

Aqueous ethanol

(95%(v / v))

1.43%w / v

-

to 100mL

components

quantity

Estradiol

Octyl Salicylate

Aqueous ethanol

(95%v / v)

1.43%w / v

5%w / v

to 100mL

[0078] Diffusion experiments were carried out as in Example 1.

[0079] Such as figure 2 As shown, the addition of octisalate, a safe sunscreen ester-type transdermal enhancer, unexpectedly significantly increased the transdermal delivery of estradiol across the skin by 1.3-fold (p<0.05).

Embodiment 3

[0081] components

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Abstract

A method of treatment or prophylaxis of amyloidosis disorders in a patient the method comprising topically applying to an area of skin of the patient a composition comprising: one or more zinc chelators; and one or more dermal penetration enhancers.

Description

technical field [0001] The present invention relates to compositions for the administration of zinc chelators such as 1,10-phenanthroline and the use of the compositions in the prevention and treatment of amyloidosis. Background technique [0002] Amyloidosis is not just one disease, but a group of diseases of acquired or hereditary origin characterized by several different types of protein filaments with similar properties called amyloid One of them was deposited extracellularly. Amyloid deposition can be a primary (primary) process with no known prodromal symptoms or a secondary process relative to certain other symptoms, and can be localized or spread throughout the body (systemic). Amyloid deposits cause a variety of common and rare diseases and may involve many different amyloid proteins. For example, Alzheimer's Disease and Creutzfeldt-Jakob disease are two distinct diseases characterized by amyloid deposits in the brain, but the proteins involved are not Not the sa...

Claims

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Application Information

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IPC IPC(8): A61K31/47A61K31/4745A61K9/12A61K31/192A61K31/60A61P25/28A61K31/00
CPCA61K9/006A61K31/47A61K31/00A61K31/60A61K31/192A61K9/7061A61K31/4745A61K9/0014A61P25/28A61K2300/00
Inventor 蒂莫西·马提亚·穆尔詹尼娜·弗朗西丝·威尔金斯
Owner ACRUX DDS
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