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Brilliant mycomycin elaioplast preparation and its making method

A technology of liposome preparation and leucectin A, which is applied in liposome delivery, antiviral agents, pharmaceutical formulations, etc., can solve problems such as limited clinical application, organic solvent allergies, human adverse reactions, etc., and achieve enhanced detoxification function , improve liver function, increase the effect of bile permeability

Inactive Publication Date: 2007-01-17
裴泽军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These organic solvents will have adverse reactions to the human body, and some patients are allergic to organic solvents, which limits their clinical application
In addition, the Tween-80 in the prescription is hemolytic, and its application in intravenous injections has been limited or even banned at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The present invention treats diseases such as acute cholecystitis, chronic cholecystitis onset, chronic superficial gastritis etc. and the process step of the preparation method of leucectin A liposome preparation is as follows: its formula composition: in g / ml:

[0028] The present invention weighs 5g of leucectin A, 50g of refined polyene phospholipids, and puts 8g of cholesterol in a round bottom flask, adds about 150ml of ethanol to the above mixture to completely dissolve into a clear solution, and puts it in a constant temperature water bath at 60°C to spin dry for 0.5 to 10 hours. Remove the solvent to form a film, and then carry out vacuum drying treatment, rotation speed: 30-100 rpm, vacuum drying: 4 hours, vacuum drying temperature: 20-60°C, vacuum degree: 0.08-0.095Mpa; plus adjust the pH: 3-10 1000ml solution containing 3g of aspartic acid, 20g of vitamin C, and 50g of mannitol to dissolve the film, ultrasonically treat with an ultrasonic instrument for 20 mi...

Embodiment 2

[0030] The process steps of the preparation method of leucectin A liposome preparation of the present invention are as follows: its formula composition: in g / ml:

[0031] The present invention weighs 10g of leucectin A, 60g of refined soybean lecithin, and puts 10g of cholesterol in a round-bottomed flask, adds about 180ml of ether to the above mixture to completely dissolve into a clear solution, puts it in a constant temperature water bath at 55°C, and spins and dries for 0.5 to 10 hours. Remove the solvent to form a film, and then carry out vacuum drying treatment, rotation speed: 30-100 rpm, vacuum drying: 4 hours, vacuum drying temperature: 20-60°C, vacuum degree: 0.08-0.095Mpa; plus adjust the pH value 1000ml of a solution containing 5g of taurine, 15g of sodium sulfite, and 50g of glucose to dissolve the film, pH value: 3-10; use a high-pressure homogenizer pump for homogenization for 25 minutes to 6 hours, and the speed of the homogenizer pump: 500-10000 rpm ; then use...

Embodiment 3

[0033] The process steps of the preparation method of leucectin A liposome preparation of the present invention are as follows: its formula composition: count in g / ml as:

[0034] Weigh 20g of leucectin A, 70g of refined lecithin, and 12g of cholesterol in a round bottom flask, add about 200ml of chloroform to the above mixture to completely dissolve into a clear solution, place in a constant temperature water bath at 50°C, and spin dry for 0.5 to 10 hours to remove the solvent Form a film, and then carry out vacuum drying treatment, rotation speed: 30-100 rpm, vacuum drying: 4 hours, vacuum drying temperature: 20-60°C, vacuum degree: 0.08-0.095Mpa; 4g of ornithine, 10g of sodium pyrosulfite, 25g of mannitol, and 25g of glucose in 1000ml to dissolve the film, pH value: 3-10; use an ultrasonic instrument for 10 minutes to 3 hours of ultrasonic treatment, ultrasonic frequency: 20-30KHZ, ultrasonic power: 1000W , and then use a high-pressure homogenizer pump to homogenate for 15 ...

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PUM

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Abstract

An armillarisin A liposome with high curative effect is prepared through dissolving armillarisin A, phosphatide and cholesterol in organic solvent, constant-temp drying for removing solvent, filming, adding vitamin, stabilizer and mannitol or glucose solution, dissolving, ultrasonic vibration or homogenizing, filtering by membrane for removing bacteria, loading in containers, filling N2 or H2 and sealing.

Description

technical field [0001] The invention relates to a leucectin A liposome preparation and a preparation method thereof, which are used for treating diseases such as acute cholecystitis, chronic cholecystitis attack, and chronic superficial gastritis, and belong to the technical field of medicine preparation. Background technique [0002] Leucicillin A can be extracted from Leucobacteria, which is the genus Pseudoarmillaria, and can also be artificially synthesized. Its properties are yellow or light yellow needle-like or crystalline powder. It has the effect of promoting bile secretion and has obvious effects on odddis sphincter. Antispasmodic effect. In addition, it may still promote immune function and enhance the phagocytosis of phagocytes, it can also reduce the activity of serum transaminases, and it can still decompose aflatoxin. It is suitable for acute cholecystitis, acute exacerbation of chronic cholecystitis, chronic gastritis and viral hepatitis. [0003] Leucectin...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/366A61K47/42A61P1/04A61P1/16A61P31/12A61K47/18A61K47/24A61K47/28
Inventor 裴泽军王丽萍
Owner 裴泽军
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