Use of chlorogenic acid in preparing medicine with liver protective efficiency
A technology of chlorogenic acid and protection, applied in the field of chlorogenic acid, can solve problems such as no report
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
experiment example 1
[0009] Experimental Example 1 Protective effect of chlorogenic acid on carbon tetrachloride-induced liver injury in rats
[0010] 1 Experimental method
[0011] Seventy-two healthy SD rats were randomly divided into 6 groups according to sex and body weight. Administered respectively by group, each mouse of negative group and model group intraperitoneally injects normal saline 1ml / 100g body weight, and each mouse of positive group (bifendate) is given 1.5% concentration bifendate 1ml / 100g body weight (150mg / kg ), and the remaining three groups were given 1ml / 100g body weight (dose 20, 10 and 5mg / kg) by intraperitoneal injection of 1ml / 100g body weight (dose 20, 10 and 5mg / kg) to each rat of each group with 0.2%, 0.1% and 0.05% chlorogenic acid crude drug liquid respectively. The above 6 groups were administered once a day for 7 days in a row. On the 7th day, the body weight of the surviving animals was weighed. One hour after the last administration, all mice in the other gro...
experiment example 2
[0018] Experimental example 2 Protective effect of chlorogenic acid on galactosamine-induced liver damage in mice
[0019] 1 Experimental method
[0020] Seventy-two healthy Kunming mice were randomly divided into 6 groups according to sex and body weight. Administration is divided into groups respectively, each rat of negative group and model group is intraperitoneally injected normal saline 0.4ml / 20g body weight, and each rat of positive group (bifendate) is fed with 0.75% concentration bifendate 0.4ml / 20g body weight (150mg / kg), and the remaining three groups were given 0.4ml / 20g body weight (dose 20, 10 and 5mg / kg) by intraperitoneal injection of 0.4ml / 20g body weight (dose 20, 10 and 5mg / kg) respectively with chlorogenic acid liquid medicine of 0.1%, 0.05% and 0.025%. Each mouse in the above 6 groups was administered once a day for 7 consecutive days. On the 7th day, the body weight of the surviving animals was weighed. One hour after the last administration, except the...
experiment example 3
[0026] Experimental example 3 Protective effect of chlorogenic acid on mouse liver injury caused by duck liver virus
[0027] 1 Experimental method
[0028] One-day-old ducklings hatched from eggs produced by healthy adult Peking ducks were inoculated intraperitoneally with 0.1 ml of duck hepatitis B virus DNA (DHBV DNA) positive virus serum. One week after the inoculation, the blood was drawn from the external jugular vein, and the positive ducks were screened out by dot hybridization with digoxin-labeled DHBV DNA probes, and the ducks were bred until they were 2 weeks old as experimental animals. As the normal control group, ducks of the same age that were not infected with the virus were used. DHBV-DNA positive ducks were randomly divided into 5 groups, which were administered intraperitoneally every morning. Administer once a day for 1 month. Measure serum ALT, AST (Rei's method) after 1 month of medication.
[0029] 2 Experimental results
[0030]
group...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More