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External use antifungal compound composition and its use

A topical composition and antifungal technology, applied in the directions of antifungal agents, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of secondary infection, poor patient compliance, and high recurrence rate

Inactive Publication Date: 2007-01-24
DIHON PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems, such as high recurrence rate, prolonged healing, and many patients suffer from
In addition, most infections have the problem of itching, and some are accompanied by inflammation, which makes the patient's compliance very poor and leads to secondary infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Butenafine Hydrochloride 10%

[0037] Mometasone Furoate 10%

[0038] Ethanol 80%

[0039] Heat to dissolve into a solution, fill in plastic or glass bottles, pour or drop a small amount for use, or fill in a spray bottle for spraying. The solution can be used in medicines, cosmetics and sanitary products.

Embodiment 2

[0041] Butenafine 5%

[0042] Mometasone Furoate 1%

[0043] Hydroxypropyl Cellulose 3%

[0044] Glycerin 20%

[0045] Water 72%

[0046] The main drug is finely ground, and partially dissolved or suspended in a matrix made of hydroxypropyl cellulose to prepare a suspension. The preparation can be used in medicines, cosmetics and sanitary products.

Embodiment 3

[0048] Ketoconazole 1%

[0049] Mometasone furoate 0.1%

[0050] Polyacrylic resin 940 2%

[0051] Triethanolamine 0.1%

[0052] Propylene Glycol 40%

[0053] Water 56.8%

[0054] Gels are prepared by conventional methods. The preparation can be used in medicines, cosmetics and sanitary products.

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PUM

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Abstract

The present invention relates to antifungal composition with two or more active components and its application in medicine, cosmetics and sanitary articles. The externally applied antifungal composition butenafine, butenafine hydrochloride or ketoconazole in 0.1-10 wt%, and mometasone furoate in 0.001-10 wt%, except substrate. Animal test shows that the antifungal composition has obvious synergistic effect in resisting Trichophyton mentagrophytes infection.

Description

technical field [0001] The invention relates to an antifungal composition containing two or more active components and its application in medicines, cosmetics and sanitary products. Background technique [0002] Fungal infectious diseases, especially superficial fungal infections, are common and frequently-occurring diseases. This infection is mainly caused by three dermatophyte genera: Trichophyton, Microsporum, and Epidermophyton. These fungal infections are contagious, and the body becomes infected when it comes into contact with the conidia produced by the filaments of the dermatophytes. Because the conidia can survive in the scales of the skin and hair, they often recur. Because the infectivity of superficial fungal infection is strong, mainly invades skin, hair, nail (toe) etc., so superficial fungal infection accounts for about 90% of the number of mycosis patients. Due to the extensive use of antibiotics and other drugs, as well as the deterioration of the internal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61P31/10A61K31/496A61K31/14
Inventor 周家礽汪伯良
Owner DIHON PHARMA GROUP
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