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Synergistic antifouling compositions comprising 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile

A technology of trifluoromethyl and chlorophenyl, applied in the field of material protection

Inactive Publication Date: 2010-06-09
JANSSEN PHARMA NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] ·Afamidazole (component II-b) has the activity similar to that of dichlorofamidazole, but it has better solubility in organic solvents, so it is easier to enter into coating preparations and impregnating agents

Method used

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  • Synergistic antifouling compositions comprising 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile
  • Synergistic antifouling compositions comprising 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile
  • Synergistic antifouling compositions comprising 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0048] 1. Toxicant Petri Dish Test in 96-well Petri Dish

[0049] Activity against algal growth was determined by the poison plate assay. Activity against algal growth was determined by the poison plate assay. Calculated amounts of stock solutions (containing 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile, pitoxazine, DCOIT, difluoro Inhibitorin or to-afluzam) was pipetted into a multi-well petri dish to achieve a final test concentration ranging from 0.05ppm to 10ppm, and mixed with warm medium. The medium was inoculated with 300 microliters of algae suspension. The multiwell dishes were maintained at 21° C., 65% relative humidity and a 16 hour daily light-dark cycle (1000 Lux photoperiod).

[0050] The minimum inhibitory concentration (MIC) was taken as the lowest concentration of each test compound or mixture of test compounds sufficient to inhibit visible growth. Take the MIC as the end of activity. The endpoints of the combination of ingre...

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PUM

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Abstract

The present invention relates to antifouling compositions and particularly to compositions which are able to provide an improved protecting effect against fouling organisms. More particularly, the present invention relates to synergistic antifouling compositions comprising an amount of at least 3.5 wt %, based on the total weight of the dry mass of the composition, of 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile, or a salt thereof, together with another biocide selected from bethoxazin, tolylfluanide, dichlofluanide, or DCOIT; for protecting materials against fouling organisms. This invention thus relates to the field of protection of materials, such as underwater objects, protection of wood, wood products, biodegradable materials and coatings.

Description

[0001] This application is a divisional application of the invention patent application with the filing date of November 5, 2002 and the application number of 02821921.X. technical field [0002] This invention relates to an antifouling composition, and more particularly to a composition which provides improved protection against fouling organic matter. In particular, the present invention relates to a synergistic antifouling composition comprising at least 3.5% by weight, based on the dry weight of the composition, of 4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)- 1H-pyrrole-3-carbonitrile or a salt thereof, together with another biocide selected from bethoxazin, dichlofluanide, or DCOIT, as an anti- Protective material for foul-smelling organic matter. Accordingly, the present invention relates to the field of material protection, such as protection of underwater objects, wood, wood products, biodegradable materials and paints. Background technique [0003] 4-Bromo-2-(4...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/10A01N43/88A01N41/04C09D201/00A01N43/80A01P15/00A01N47/04C09D5/14A01N43/36C09D5/16
CPCC09D5/1625A01N43/36
Inventor M·A·J·范德弗拉尔斯J·R·尼斯
Owner JANSSEN PHARMA NV