Preparation of gardenia jasminoides by membrane separation technology

A gardenia extract, membrane separation technology, applied in the direction of membrane technology, semipermeable membrane separation, carboxylate preparation, etc., can solve the problems of difficult storage, easy moisture absorption of products, etc., to reduce production costs, improve separation and purification efficiency, Effect of improving yield and quality

Inactive Publication Date: 2007-04-04
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The Gardenia jasminoides extract prepared with a hydrophilic solvent contains main medicinal active ingredients such as gardenia iridoid glycosides, carotenoids or organic acids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0033] Example 1

[0034] Using gardenia produced in Fujian as raw material, the fresh gardenias are washed, dried (air-dried, dried or sun-dried), crushed, and sieved through 20-30 mesh to obtain gardenia powder. Put 2.9kg of gardenia powder into the extraction tank In, using 10 times dry weight (W / W) of gardenia powder (W / W) of 40% methanol-acetone (1:1) aqueous solution, reflux and extract 3 times at 68°C for 2 hours each time, combine the extracts, filter, The filtrate is under the conditions of -0.06~-0.095MPa, 50~80℃, the solvent is recovered under reduced pressure, and it is concentrated in vacuo to form a gardenia extract. After testing, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 93.2%, 96.3% and 93.1%, respectively.

[0035] Then, the crude gardenia extract was mixed with appropriate amount of water to form a suspension to make the specific gravity of the suspension reach 1.03, and then a polysulfone membrane with a molecula...

Example Embodiment

[0036] Example 2

[0037] Put 2.6 kg of gardenia powder of 20-30 mesh into the extraction tank, use 15 times dry weight (W / W) of gardenia powder in 25% methanol aqueous solution, extract twice at 50℃, 3 hours each time, combine The extract was filtered, and the filtrate was recovered under reduced pressure under the conditions of -0.06~-0.095MPa and 50~80°C to recover the solvent and concentrate in vacuo to form a gardenia extract. After testing, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 92.3%, 92.8% and 91.8%, respectively.

[0038] Stir the crude gardenia extract with appropriate amount of water to form a suspension to make the specific gravity of the suspension reach 1.12, and then use a polyvinylidene fluoride membrane with a molecular weight cut-off of 30,000 to separate and remove impurities at 0.60MPa to remove protein, polysaccharides and other After the macromolecular impurities, the gardenia extract after membrane separati...

Example Embodiment

[0039] Example 3

[0040] Put 2.7 kg of gardenia powder of 20-30 mesh into the extraction tank, use 5 times dry weight (W / W) of gardenia powder in 75% methanol aqueous solution, reflux and extract at 80℃ for 1 hour, filter, and filter the filtrate in- Under the conditions of 0.06~-0.095MPa and 50~80℃, the solvent was recovered under reduced pressure and concentrated in vacuo to form a gardenia extract. After testing, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 95.6%, 95.0% and 93.5%, respectively.

[0041] Stir the crude gardenia extract with appropriate amount of water to form a suspension to make the specific gravity of the suspension reach 1.03, and then use an inorganic ceramic membrane with a membrane pore size of 0.22μm to separate and remove impurities at 0.25MPa to remove protein and polysaccharides and other large molecules After impurities, the gardenia extract after membrane separation and purification is obtained. After de...

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PUM

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Abstract

A process for preparing the extract from capejasmine fruit by use of membrane separation technique includes such steps as extracting in hydrophilic solvent to obtain coarse extract, adding water to become suspension, and membrane separation for removing protein, polyose and other macromolecular impurities.

Description

technical field [0001] The invention relates to a green chemical preparation method for extracting and separating medicinal active ingredients from plants, and more specifically relates to a method for preparing gardenia jasmine extract by adopting membrane separation technology. Background technique [0002] Gardenia is the fruit of the evergreen shrub Gardenia (Gardenia) Rubiaceae (Rubiaceae), which is a large amount of traditional Chinese medicinal materials in China. The main medicinal ingredients of Lingling Injection, Longdan Xiegan Tablets and Yindan Pinggan Capsules are the first-choice drugs for the clinical treatment of jaundice hepatitis in traditional Chinese medicine and the raw materials for extracting natural pigments from gardenia. They are abundant in Fujian, Zhejiang, Jiangxi, Huizhou, Mountainous areas in Hunan and other provinces. [0003] Gardenia has been recorded in famous medical works of all dynasties from "Compendium of Materia Medica" to "Chinese ...

Claims

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Application Information

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IPC IPC(8): A61K36/744C07B63/00C07C403/24C07C51/47C07C67/56B01D71/02B01D71/08B01D71/34B01D71/56
Inventor 陈剑锋郭养浩陈浩
Owner FUZHOU UNIVERSITY
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