2-phenoxy chromone heteroside compounds and its preparing method and use

A technology of phenoxy chromone and proketone glycosides, which is applied in the preparation of 2-phenoxy chromone glycosides for the treatment of antiviral or immunosuppressant or hyperlipidemia drugs or health care products

Inactive Publication Date: 2007-04-11
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • 2-phenoxy chromone heteroside compounds and its preparing method and use
  • 2-phenoxy chromone heteroside compounds and its preparing method and use
  • 2-phenoxy chromone heteroside compounds and its preparing method and use

Examples

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Embodiment 1

[0078] Take 2 kg of dried whole Artemisia argyi, heat and reflux with 8 times 60% ethanol solution to obtain the extract;

[0079] Concentrate the extract under reduced pressure at 50°C into a paste, suspend it with 1500ml of water, extract with petroleum ether, ethyl acetate, and n-butanol respectively, recover the n-butanol extract, and concentrate under reduced pressure to extract;

[0080] The extract was dissolved in 500ml of ethanol, mixed with 1 times of silica gel, evaporated the solvent with a rotary evaporator, dried, separated by silica gel column chromatography, packed with 5 times the total sample weight of silica gel column 100 mesh, ethyl acetate: ethanol 100:1 Gradient elution, combined ethyl acetate: ethanol 100: 1 effluent, concentrated and then silica gel column chromatography, ethyl acetate: ethanol gradient elution, silica gel thin layer plate chromatography detection, the same fractions were combined to obtain the The crude compound was finally recrystall...

Embodiment 2

[0082] Take 2 kg of dried whole Artemisia argyi, heat and reflux with 9 times 65% ethanol solution to obtain the extract;

[0083] Concentrate the extract under reduced pressure at 60°C into a paste, suspend it with 1500ml of water, extract with petroleum ether, ethyl acetate, and n-butanol respectively, recover the n-butanol extract, and concentrate under reduced pressure to extract;

[0084] The extract is dissolved in 500ml of ethanol, 1 times of silica gel is used to mix the sample, and the solvent is evaporated with a rotary evaporator, dried, separated by silica gel column chromatography, packed with 150 meshes of silica gel column with 5 times the total weight of the sample, ethyl acetate: ethanol (100: 80) Gradient elution, combined ethyl acetate: ethanol (100: 1) effluent, concentrated and then performed silica gel column chromatography, using ethyl acetate: ethanol gradient elution, silica gel thin layer plate chromatography detection, the same fraction Combined to o...

Embodiment 3

[0086] Take 2 kg of dried whole Artemisia argyi, heat and reflux with 10 times 70% ethanol solution to obtain the extract;

[0087] Concentrate the extract under reduced pressure at 70°C into a paste, suspend it with 1500ml of water, extract with petroleum ether, ethyl acetate, and n-butanol respectively, recover the n-butanol extract, and concentrate under reduced pressure to extract;

[0088] The extract was dissolved in 500ml of ethanol, mixed with 1 times of silica gel, evaporated the solvent with a rotary evaporator, dried, separated by silica gel column chromatography, packed with 5 times the total sample weight of silica gel column 200 mesh, ethyl acetate: ethanol 80:50 Gradient elution, combined ethyl acetate: ethanol 100: 1 effluent, concentrated and then silica gel column chromatography, ethyl acetate: ethanol gradient elution, silica gel thin layer plate chromatography detection, the same fractions were combined to obtain the The crude compound was finally recrystal...

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Abstract

The present invention relates to one kind of 2-phenoxy chromone glycoside compound and its preparation process and use. The compound is separated from alpine yarrow herb, and is named chemically as 6-demethoxy-4'-O-methyl capillarisin-7-O-beta-D-glucoside. Its structure has been determined through physical and chemical constant measurement and spectral data analysis, and initial activity screening test proves its antiviral, immune suppressing and blood fat reducing activity.

Description

technical field [0001] The present invention relates to a medicinal 2-phenoxychromone glycoside compound and its preparation method and use. Specifically, the whole herb of Artemisia annua is used as a raw material to prepare a 2-phenoxychromone glycoside compound and used as a therapeutic agent. Use of antiviral or immunosuppressant or hyperlipidemic drugs or health care products. Background technique [0002] Artemisia rupestris L. is a plant of the Compositae family, Artemisia rupestris L., and the whole herb is used as medicine. It is called "Yizihu Emani" in Uighur and "Yizihu" in Kazakh. It has a long history of folk medicine in Xinjiang. It has the effects of clearing away heat and detoxification, invigorating the stomach, benefiting the gallbladder, and detoxifying snake poison. For indigestion, abdominal pain, hepatitis, urticaria, snake bites, cold and fever. Mainly distributed in Xinjiang, China, Central Asia, Europe and other places. Thi...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61K36/28A61P31/12A61P37/06A61P3/06A23L1/30A61K127/00A23L33/105
Inventor 阿吉艾克拜尔·艾萨赵芸宿珍吕俏莹
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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