Method for preparing 3-formacyl chromone derivative

Abstract

The invention relates to a 3-formacyl chromone derivative preparing method, making bis(trichloromethyl) carbonate fully react with N,N-dimethylformamide in C1-C4 halogenated hydrocarbon solvent at 0-5 deg.C, then adding in C1-C4 halogenated hydrocarbon solution of 2-hydroxy acetophenone derivative, raising temperature to 25-30 deg.C to react for 12-16 hours, separating and purifying the resultant and obtaining the 3-formacyl chromone derivative. And it has advantages of raw materials easy to obtain, reacting conditions moderate, simple and convenient to operate, clean and less pollution, good product purity, and high product yield; and it is a chemical synthesizing method with better spreading application prospect.

Description

(1) Technical field

[0001] The invention relates to a preparation method of 3-formyl chromone derivatives. (2) Background technology

[0002] The 3-formyl chromone derivative itself has important pharmacological activities such as antibacterial, antiviral, blood lipid lowering, and preventing arrhythmia, and is also a widely used drug intermediate. 3-formyl chromone derivatives have three electron-deficient sites (C-2, C-4, -CH=O), which can react with different types of nucleophiles to obtain a large number of heterocyclic compounds. In the field of pharmaceuticals, the potential pharmacological activity of 3-formylchromone and its functionalized derivatives are used as the preferred active group for the design of various therapeutic drugs such as diabetes and obesity. In the chemical industry, 3-formyl chromone and its derivatives can also be used to synthesize photosensitizers, which are widely used in the image production industry. The 3-heterocyclic substituted chromo...

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