Application of phillyrin in preparation for treating endotoxemia

A technology of endotoxemia and forsythin, which is applied in the field of application of forsythin in the preparation of preparations for the treatment of endotoxemia, and can solve problems that have not yet been developed into a treatment method

Inactive Publication Date: 2007-05-02
崔乃杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, there has not been developed an effec...

Method used

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  • Application of phillyrin in preparation for treating endotoxemia
  • Application of phillyrin in preparation for treating endotoxemia
  • Application of phillyrin in preparation for treating endotoxemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Oral enteric-coated capsules:

[0154] Weigh 2 kg of forsythin crude crystals and 60 kg of medical starch, mix well, and put them into No. 5 hollow enteric-coated capsules, so that each capsule contains 4 mg of forsythin coarse crystals, and the total weight of each capsule is 0.12 g , for oral use.

Embodiment 2

[0155] Embodiment 2: intravenous injection:

[0156] Forsythin solution was prepared by dissolving 2mg of refined forsythin in 1ml of 50% pure ethanol; then diluted with water for injection to a total of 10ml, and then filtered three times sequentially, first pre-filtered with F2300G-60 titanium filter , the filtrate is filtered with a nuclear microporous filter membrane (0.45 μm), and finally sterile filtered with a 0.22 μm filter membrane, mechanically potted, and made into an injection with a dose of 2mg / 10mL / ampere for intravenous injection. .

[0157] The purity and concentration of forsythin in the preparation can be determined by ultraviolet spectrophotometry and infrared spectroscopy.

[0158] UV spectrum λ max MeOH (logε): 274;

[0159] Infrared spectrum U max KBr cm -1 : 3380(-OH), 1610, 1598, 1520(C=C)

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Abstract

An application of forsythin in preparing the medicines for treating endotoxemia is disclosed.

Description

technical field [0001] The invention relates to a systemic protective drug or an antidote, in particular to the application of forsythin in the preparation of a preparation for treating endotoxemia. Background technique [0002] Endotoxin and endotoxemia are the main causes of sepsis. Sepsis is a common critical disease in various clinical disciplines, especially in the intensive care unit. With the increasing number of patients worldwide with aging population, cancer, multiple trauma, diabetes, cerebrovascular accident and organ transplantation, as well as the increasing application of interventional therapy, chemotherapy, radiotherapy, immunosuppressant, etc., the incidence of sepsis is increasing year by year. trend. It is well known that sepsis is associated with severe Gram-negative bacilli infection and endotoxins (including intestinal bacteria-toxin translocation), and is the main cause of infectious multiple organ dysfunction syndrome (MODS). In addition, in recent...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/04A61P7/00A61P39/02A61P43/00
Inventor 崔乃杰傅强崔华雷崔乃强王士贤
Owner 崔乃杰
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