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Traditional Chinese medicinal compound preparation for treating asthma and its preparation method

A technology for compound preparations and asthma, which is applied in the field of compound preparations of traditional Chinese medicine, and can solve the problems that patients cannot effectively prevent recurrence, do not cure the root cause, and have unsatisfactory effects.

Inactive Publication Date: 2007-05-02
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medicine believes that asthma is a chronic airway inflammation involving eosinophils, mast cells, T lymphocytes and other inflammatory cells. Therefore, Western medicine treatment mainly focuses on anti-inflammatory and antispasmodic agents. The market mainly uses corticosteroid inhalants. , adrenaline inhalers, other asthma inhalants, systemic epinephrine and other Western medicines are dominant. Although these drugs have a relatively rapid effect and are easy to relieve symptoms in patients with acute attacks, they "only treat the symptoms, not the root cause". Only pay attention to asthma relief, but chronic eosinophilic bronchial inflammation, which is the root cause of asthma recurrence, has not been eliminated. As long as an allergen is encountered at any time, asthma will definitely be induced, and the relapse cannot be effectively prevented for patients in the remission period, so the effect is not ideal and there is a certain risk. side effects of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Example 1: 1 part of Epimedium, 1 part of Huhuanglian, 1 part of Houttuynia cordata

[0099]Take Epimedium medicinal material, add 10 times the volume of 70% ethanol to reflux and extract 3 times, each time for 1 hour, combine the extracts, recover the ethanol under reduced pressure and measure the relative density to 1.05-1.15 at 60°C, add water 4 times the volume of the medicinal material Dissolve, filter, and pass the filtrate through the polyamide column at a speed of 0.5ml / g medicinal material.min, wash the impurities with water 7 times the volume of polyamide in turn, then desorb with 60% ethanol 5 times the volume of polyamide, collect the desorption liquid, and decompress When recovering ethanol to 60°C, the relative density was measured to be 1.05-1.15, and dried to obtain Epimedium extract I. Add 10 times the amount of water to decoct Epimedium dregs for 3 times, each time for 1.0 hour, combine the extracts, and concentrate to 60 Measure the relative density a...

Embodiment 2

[0100] Embodiment 2: 99 parts of Epimedium, 1 part of Huhuanglian, 99 parts of Houttuynia cordata

[0101] Take Epimedium medicinal material, add 8 times the volume of 80% ethanol to reflux and extract twice, each time for 2.0 hours, combine the extracts, recover the ethanol under reduced pressure and measure the relative density to 1.05-1.15 at 60°C, add water 3 times the volume of the medicinal material Dissolve, filter, pass the filtrate through the polyamide column at a speed of 0.5ml / g medicinal material.min, wash the impurities with 5 times the volume of polyamide in water, and desorb with 50% ethanol 4 times the volume of polyamide, collect the desorption liquid, and recover under reduced pressure When the ethanol reaches 60°C, the relative density is 1.05-1.15, and dried to obtain Epimedium extract I; Epimedium dregs are decocted with 10 times the amount of water for 3 times, each time for 1.0 hour, the combined extracts are concentrated to 60°C When measuring the rela...

Embodiment 3

[0102] Embodiment 3: 50 parts of Epimedium, 50 parts of Coptis chinensis, 50 parts of Houttuynia cordata

[0103] Take Epimedium medicinal material, add 12 times the volume of 80% ethanol to reflux and extract for 2.5 hours, and recover the ethanol from the extract under reduced pressure to 60°C to measure the relative density of 1.05-1.15, add 4 times the volume of the medicinal material to dissolve, filter, and the filtrate is 0.8 The speed of ml / g medicinal materials.min passes through the polyamide column, and the impurities are washed with 8 times the volume of polyamide water in sequence, and then desorbed with 5 times the volume of polyamide 50% ethanol, the desorption solution is collected, and the ethanol is recovered under reduced pressure to 60 ° C to measure the relative Density is 1.05~1.15, dried to obtain Epimedium extract I; Epimedium dregs is added with 10 times the amount of water and decocted 3 times, each time for 1.5 hours, the combined extracts are concent...

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Abstract

A composite medicine in the form of injection or orally taken solid or liquid for treating asthmatic chronic bronchitis, acute bronchal asthma, lung infection, pneumonia, pneumonectasis, cardiogenic asthma, pulmonary tuberculosis, silicosis, etc is prepared from epimedium or its extract, picrorhiza rhizome or its extract, and houttuynia or its extract. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating asthma, and provides a preparation method of the compound preparation, which belongs to the technical field of traditional Chinese medicine. technical background [0002] Asthma is a global, one of the most common clinical chronic diseases that are difficult to cure and prone to repeated attacks. There are about 160 million patients in the world. Survey reports from several foreign countries indicate that the prevalence of asthma in children is 0.2% to 7.4%, and the prevalence of asthma in adults is 1.1% to 9.9%. The prevalence of asthma in my country is about 0.5% to 2.0% according to local area surveys, and it has also been reported as high as 5.29%. Asthma can occur at any age and affects men and women roughly equally in adults. With the continuous improvement of the degree of industrialization, due to the aggravation of air pollution and the development of c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K36/718A61K36/296A61P11/06
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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