Double function infusion protein for thrombolysis and anticoagulation , its preparation method and uses

A dual-efficiency, fusion protein technology, applied in chemical instruments and methods, peptide/protein components, animal/human proteins, etc., can solve problems such as adverse effects of curative effect stability
CN1970574AInactive Publication Date: 2007-05-30CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2007-05-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a fusing protein with plasminokin and anticoagulant function and DNA sequence to code the fusing protein, carrier with the DNA sequence and making method of fusing protein, which provides the application of fusing protein to prepare functional drug with peptide segment of continuous amino acid sequence as connecting structure, wherein the fusing protein connects 10-12 amino acids in the 55-66th amino acids sequence at IIIC end of hirudin with r-PA as t-PA bobbing mutant.
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Description

technical field

[0001] The present invention relates to a fusion protein with dual effects of thrombolysis and anticoagulation obtained by DNA recombination, a DNA sequence encoding the fusion protein, a carrier containing the DNA sequence, a preparation method of the fusion protein, and the fusion protein is prepared The application of drugs with thrombolytic and anticoagulant effects, and the application of peptides composed of continuous glycine sequences as linking structures in the preparation of fusion proteins with dual functions of thrombolytic and anticoagulant. Background technique

[0002] Thrombolytic drugs and anticoagulant drugs are currently two types of drugs for the treatment of thrombotic diseases.

[0003] As the first generation of thrombolytic drugs, there are staphylokinase (SAK), streptokinase (SK), urokinase (UK) and so on. Human tissue plasminogen activator (t-PA) containing 527 amino acids is a second-generation thrombolytic drug with high specific...

Claims

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