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Biological surgical patch

A biological and surgical technology, applied in the field of medical products, can solve the problems of unsatisfactory repair effect, large cytotoxicity, difficult to grow together, etc., and achieve the effect of good mechanical compliance, good biocompatibility, and mechanical requirements.

Active Publication Date: 2007-06-27
GRANDHOPE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the fixation of glutaraldehyde to the tissue is cross-linked and fixed by acetal reaction. When it degrades, glutaraldehyde will be released, which has residual toxicity of aldehyde, showing greater cytotoxicity, and it is difficult to grow with the original tissue. Put together, the repair effect is not ideal

Method used

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  • Biological surgical patch

Examples

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Effect test

Embodiment 1

[0025] Example 1, as shown in Figure 1, a biological surgical patch, a substrate 1 formed of porcine or bovine pericardium that has been cross-linked and fixed by a non-aldehyde fixative, treated with antigen removal, and modified by protein toughening, and The active surface layer 2 is composed of specific polypeptides or glycosaminoglycan active components coupled on the surface of the substrate 1, where one of the specific polypeptides is composed of 16 lysine (K16), glycine (G), Arginine (R), aspartic acid (D), serine (S), proline (P) and cysteine ​​(C) polycondensate, the glycosaminoglycan is hyaluronic acid , chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, or keratan sulfate. Both upper and lower surfaces of the substrate 1 are provided with an active surface layer 2 .

[0026] The preparation method of the biological surgical patch is as follows: the pericardium of pig or bovine is used as the base material, and it is made according to the following st...

Embodiment 2

[0036] Embodiment 2: As shown in accompanying drawing 1, take pig diaphragm or pleura as base material, sterilize according to the method for embodiment 1, trim, alkali treatment, after degreasing, use diamide as cross-linking fixative, use methyl The chemical reagent will be -OH, -NH 2 methylation, treatment with guanidine hydrochloride solution to change specific conformation, diisocyanate as initiator to graft polyurethane prepolymer to collagen molecules of substrate 1, carbodiimide as coupling agent, and other technical features It is the same as that in Embodiment 1 and will not be repeated here.

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PUM

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Abstract

The present invention discloses biological surgical patch and its preparation process. The biological surgical patch includes one base material of animal membrane material, which is cross-linking fixed with non-aldehyde fixing agent and treated to eliminate antigen. The biological surgical patch made of natural biological material with collagen as main component may be degraded in the degradation speed synchronizing with the growth of the regenerating tissue, and the degraded products are amino acids or polypeptide capable of being absorbed by organism for the regenerative repair of the defected tissue. The present invention has no immunological rejection reaction, high biocompatibility, capacity of inducing tissue regeneration and good mechanical compliance, and can meet the requirement for repairing tissue.

Description

technical field [0001] The invention relates to a medical product used for repairing tissues or organs in surgical operations, which belongs to implanted medical equipment. Background technique [0002] In modern surgical operations, it is often necessary to repair some defective tissues and organs, such as the repair of dura / spinal defect, the repair of pleural defect, the repair of peritoneal defect, the tension-free repair of hernia, the repair of diaphragm, and the repair of blood vessels. Repair, repair of atrial diaphragm, repair of pericardium, repair of bladder, etc. In order to meet the needs of these repairs, there are many kinds of "surgical patches" supplying clinical needs at home and abroad. But most of them are made of synthetic materials. The materials used to make surgical patches include: polypropylene, polyethylene, polyamide, polyester resin, polytetrafluoroethylene, silicone rubber, carbon fiber, etc., which are permanent foreign bodies It exists in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00
CPCA61L27/3604A61L27/3683
Inventor 徐国风
Owner GRANDHOPE BIOTECH CO LTD
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