Highly effective Chinese medicine-chitosan compound hemostatic material

A technology of hemostatic material and chitosan, which is applied in the fields of plant raw materials, pharmaceutical science, pharmaceutical formulations, etc., can solve the problems of poor hemostatic effect and poor mechanical properties, and achieves good hemostatic effect, good mechanical properties and high adsorption capacity. Effect

Inactive Publication Date: 2007-07-11
LIAONING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan has excellent properties such as hemostasis, pain relief, promotion of wound healing, scar reduction, antibacterial, good physiological compatibility and biodegradability, and is very suitable as a raw material for wound dressings. The film is brittle, has poor mechanical properties, and poor hemostatic effect. Therefore, it needs to be combined with other materials to effectively combine the excellent properties of different materials, thereby improving its mechanical properties and strengthening the hemostatic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1 10

[0012] The preparation of example 1 Panax notoginseng-chitosan composite hemostatic material

[0013] Add chitosan with a deacetylation degree of 75-98% to the acetic acid solution and stir for 2 hours to prepare a chitosan-acetic acid solution with a concentration of 1-2%, filter the impurities and insolubles therein with filter paper, and put the filtrate into dialysis The bag is soaked in phosphate buffer solution for dialysis, and the buffer solution is changed every 6 to 12 hours for 3 to 4 times. Take out the chitosan solution, add gelatin and glycerin and stir for 30 minutes, then add Panax notoginseng powder, stir quickly until uniform. Pour it into a glass dish, let it stand for 30 minutes, and freeze-dry it in a vacuum freeze dryer to obtain a composite hemostatic material. After the finished product is sterilized, it is packaged and sealed in plastic wrap.

example 2

[0014] Preparation of Example 2 Bletilla striata-chitosan composite hemostatic material

[0015] Bletilla striata-chitosan composite hemostatic material was prepared according to the method of Example 1.

example 3 10

[0016] Example 3 Preparation of Sanqi-Bletilla striata-chitosan composite hemostatic material

[0017] Add chitosan with a deacetylation degree of 75-98% to the acetic acid solution and stir for 2 hours to prepare a chitosan-acetic acid solution with a concentration of 1-2%, filter the impurities and insolubles therein with filter paper, and put the filtrate into dialysis The bag is soaked in phosphate buffer solution for dialysis, and the buffer solution is changed every 6 to 12 hours for 3 to 4 times. Take out the chitosan solution, add gelatin and glycerin and stir for 30 minutes, then add notoginseng and bletilla striata powder (weight ratio 1:3), and stir quickly until uniform. Pour it into a glass dish, let it stand for 30 minutes, and freeze-dry it in a vacuum freeze dryer to obtain a composite hemostatic material. After the finished product is sterilized, it is packaged and sealed in plastic wrap.

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PUM

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Abstract

The invention relates to a high-effect Chinese traditional drug-chitose hemostatic material, since chitose has better hemostatic function, wherein its preparation comprises that: adding 8-17 deals of hemostatic with 75-98% deacetylated degree into acetate solution to prepare chitose acetate solution; filtering out the foreign materials via filter paper; putting filter solution into dialysis bag; immerging it into phosphate buffer solution to dialyze; changing buffer solution each 6-12h; taking out chitose solution, adding 28-50 deals medical biological findings and glycerin, mixing for 30min, adding 35-60 deals hemostatic traditional drug powder, to be mixed uniformly; pouring into glass container; laying for 30min; drying and freezing in vacuum freezing drier, to obtain the composite hemostatic material.

Description

1. Technical field [0001] The invention relates to a novel high-efficiency traditional Chinese medicine-chitosan composite hemostatic material, which belongs to the invention in the field of biopharmaceutical materials. 2. Background technology [0002] Due to the unique and excellent biological activity of chitosan, its research on wound dressing has gradually become a hotspot in the application research of biomaterials. Chitosan has excellent properties such as hemostasis, pain relief, promotion of wound healing, scar reduction, antibacterial, good physiological compatibility and biodegradability, and is very suitable as a raw material for wound dressings. The film is brittle, has poor mechanical properties, and poor hemostatic effect. Therefore, it needs to be compounded with other materials to effectively combine the excellent properties of different materials, thereby improving its mechanical properties and strengthening the hemostatic effect. 3. Contents of the inven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/06A61L31/12A61K36/898A61K36/258
Inventor 李继平杨冬雪王孝敏许永廷
Owner LIAONING NORMAL UNIVERSITY
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