Naturally extracted and synthetic hypoglycemic or hypolipidemic compositions

Abstract

Compositions having hypoglycemic and / or hypolipidemic activity are isolated from natural sources including yeast and Saltbush (Atriplex halimus). In addition, synthetic chromium complexes were prepared. Compositions possessing hypoglycemic and / or hypolipidemic activity with or without chromium containing natural and synthetic compounds are formulated for use in animals and humans. Methods for use of the compositions alone, or in combination with antioxidant agents, for regulating glucose and lipid levels in diabetes, cardiovascular diseases, inflammatory and cell proliferative diseases and in skin conditions, are presented.

Description

[0001] The present invention is directed to processes of isolating purified compositions with or without chromium containing compounds, from a variety of natural sources including, but not limited to, a yeast strain S. carlsbergensis, or S. cerevisiae, or any commercial source of yeast extract; or from the Saltbush, Atriplex halimus, growing in the Negev Desert near the Dead Sea and other and areas in the middle east. The invention also comprises production of synthetic sources of chromium, including, but not limited to chromium gluconate, chromium sulfate, chromium-cysteine, chromium-N-acetyl cysteine, chromium-glutathione, chromium acetate, chromium citrate, chromium ascorbate or chromium tartarate. The invention is also directed to formulations with or without chromium containing natural compounds or the synthetic chromium complexes, which specifically regulate glucose tolerance, glucose and lipid metabolism, insulin action, and metabolic activities in mammals who may be at an en...

AI Technical Summary

Benefits of technology

[0010] The present invention also provides methods for the synthesis of chromium complexes, which are pure and can be prepared in large quantities without possibility of contamination.

[0019] It is also the object of the present invention to provide formulations having hypoglycemic and / or hypolipidemic activity, with or without chromium containing natural and synthetic compositions which are effective when used alone or in combination with antioxidants or conventional therapies.

[0021] It is also an object of the present invention to provide methods for the synthesis of chromium complexes which are pure and can be prepared in large quantities without possibility of contamination.

Problems solved by technology

These metabolic abnormalities, in general, are associated with risk for and / or incidence of diabetes.

Malnutrition associated with Cr deficiency brings an impaired glucose tolerance.

However, inorganic Cr compounds are poorly absorbed by the gut, whereas organic Cr components are well absorbed in the body.

Although genetic and immunologic markers for IDDM have been identified, they are not enough nor sensitive enough to be used to define IDDM or distinguish IDDM and NIDDM.

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