Process for the preparation of [S(-) amlodipine - L (+)- hemitartarate]
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EXAMPLE-2
[0018] RS Amlodipine L(+)tartarate mono DMSO Solvate from RS Amlodipine
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[0019] The procedure as described in example 1 was repeated and the reaction was kept overnight. The solid filtered and dried to yeidl 14 gm, 97.9% RS Amlodipien L(+) tartarate mono DMSO solvate. Mp 148.5-151.degree. C. (c=1 MeOH) 3.3% de by chiral HPLC.
Example
EXAMPLE-3
[0020] S(-)Amlodipine hemi L(+)tartarate monohydrate from S(-) Amlodipine-hemi-L-(+)tartarate monohydrate DMSO Solvate--Methanol as Solvent.
[0021] 50 gms of S(-) Amlodipine-hemi-L(+)-tartarate mohohydrate DMSO solvate was dissolved in 250 ml refluxing methanol (30 min). The solution was kept overnight at room temperature (25-28.degree. C.) with stirring. The solid was collected by filtration, washed with 100 ml methanol and dried at 50.degree. C. in vacuo (2 hrs till constant wt.) to give 35 gm (80%). S(-)Amlodipine-hemi-L(+)-tartarate monohydrate. Mp 171-172.degree. C.=114.1 (c=1, MeOH); 90% de chiral HPLC.
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