Uses of thioredoxin

a technology of thioredoxin and thioredoxin, which is applied in the field of thioredoxin, can solve the problems of limited md treatment, decreased sensitivity of these cells, and the inability of cys73.fwdarw.ser mutant and other mutant thioredoxins to stimulate cell proliferation, so as to reduce or increase the sensitivity of tumor cells

Inactive Publication Date: 2003-12-04
PROLX PHARMA +1
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  • Description
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Problems solved by technology

However, the mechanism for cell growth stimulation by thioredoxin mRNA has been examined and found not to promote cell growth.
However, the ability of the Cys73.fwdarw.Ser mutant and other mutant thioredoxins to stimulate cell proliferation has not been reported.
However, it has not been disclosed or suggested in the art that thioredoxin reductase be used as an anti-tumor drug target.
Thus, current treatment for MD is limited by the ability of cytokines to stimulate hematopoietic progenitor cells and the decreased sensitivity of these cells to growth factors.

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Embodiment Construction

[0064] All of the various publications cited in the present specification are incorporated by reference in their entireties.

[0065] 4.1 Definitions

[0066] In order that the invention herein described may be fully understood, the following definitions are provided:

[0067] "Nucleotide" means a monomeric unit of DNA or RNA consisting of a sugar moiety (pentose), a phosphate, and a nitrogenous heterocyclic base. The base is linked to the sugar moiety via the glycosidic carbon (1' carbon of the pentose) and that combination of base and sugar is called a "nucleoside". The base characterizes the nucleotide. The four DNA bases are adenine ("A"), guanine ("G"), cytosine ("C"), and thymine ("T"). In RNA uracil ( "U") substitutes for T. In double stranded molecules, an A on one strand pairs with T(U) on the other, and G with C. As is conventional for convenience in the structural representation of a DNA nucleotide sequence only one strand is shown in which A on one strand connotes T on its comple...

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Abstract

The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.

Description

[0001] This is a continuation of application U.S. Ser. No. 09 / 319,292, filed on Jun. 3, 1999, which is a national phase filing based on International Application No. PCT / US97 / 22292, filed on Dec. 5, 1997, which claimed the benefit of priority from U.S. Provisional Patent Application Serial No. 60 / 031,995, filed on Dec. 6, 1996.1. BACKGROUND OF INVENTION[0003] The present invention generally relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or eliminating thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.[0004] Thioredoxin is a low molecular weight (M.sub.r 11,000-12,000) redox protein found in both prokaryotic and eukaryotic cells. (Holmgren A., J. Biol. Chem., 264:13963-13966, 1989), that undergoes reversible thiol reduction by the NADPH-dependent enzyme thioredoxin reductase. Human thioredoxin, which has 5 cysteine (Cys) residue...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/44A61K48/00G01N33/50G01N33/573
CPCA61K38/44A61K48/00G01N2333/90209G01N33/573G01N33/5011A61P35/00
Inventor POWIS, GARTH
Owner PROLX PHARMA
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