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Ultrasonic contrast agent detection and imaging by low frequency manipulation of high frequency scattering properties

a technology of high frequency scattering and contrast agent, applied in diagnostics, applications, reradiation, etc., can solve the problems of high transmission amplitude, low image resolution typical obtained with harmonic imaging, and the destruction of contrast agent bubbles

Inactive Publication Date: 2004-12-30
ANGELSEN BJORN A J +1
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Problems solved by technology

The consequence of a relatively narrowbanded and low frequency drive pulse is the low image resolution typically obtained with harmonic imaging.
Also, the received nonlinear harmonic component from the contrast agent typically has low amplitude which reduces the CNR and may require so high transmitted amplitude that the contrast agent bubbles are destroyed.
This can cause a problem when the inflow rate of contrast agent to the tissue region is low.
Finally, a limitation in all methods based on nonlinear harmonic detection is that nonlinear components in the tissue signal is preserved in the process, also limiting the CTR.

Method used

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  • Ultrasonic contrast agent detection and imaging by low frequency manipulation of high frequency scattering properties
  • Ultrasonic contrast agent detection and imaging by low frequency manipulation of high frequency scattering properties
  • Ultrasonic contrast agent detection and imaging by low frequency manipulation of high frequency scattering properties

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Embodiment Construction

[0037] The invention will now be described in more detail with reference to the figures.

[0038] For small amplitude radius excursions, the mathematical equations governing contrast bubble oscillation can be linearized and we obtain the following transfer function from drive pressure to radial bubble displacement 1 H 1( ) =12 - 1 - i d where d =b0 m,0 2 = s m , = 0

[0039] Here, .omega. is the angular frequency and .omega..sub.0 is the resonance frequency of the bubble while s is the stiffness of the gas and shell, m is the inertia of the surrounding liquid, and d is a damping factor of the resonant system.

[0040] The absolute value and phase angle of H.sub.1(.OMEGA.) is shown in the upper and lower panel in FIG. 1a, respectively. In the lower panel, we see that for drive frequencies well below resonance the displacement is .pi. out of phase with the driving pressure. For frequencies well above resonance the bubble responds differently and the displacement and drive pressure are now in p...

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Abstract

A method for improved detection and imaging of ultrasound contrast agents using dual-band transmitted pulses, is described. The method is based on transmitting a pulse consisting of two frequency bands, a low frequency band which purpose is to manipulate the high frequency scattering properties of the contrast agent, and a high frequency band from which the image reconstruction is based. In addition, a general form of pulse subtraction is used to significantly suppress the received tissue signal.

Description

[0001] This application claims priority from U.S. Provisional Patent Application Ser. No. 60 / 475,222 which was filed on May 30, 2003.[0002] 1. Field of the Invention[0003] This invention relates to methods and systems for ultrasonic detection and imaging of contrast agents located in soft tissue or tissue fluids.[0004] 2. Description of the Related Art[0005] Ultrasound contrast agents are typically made as solutions of micro gas bubbles or nano lipid particles. The gas bubbles typically show strong and nonlinear scattering of the ultrasound, a phenomenon that is used to differentiate the contrast agent signal from the tissue signal. In the earliest applications (.about.1985) the increased scattering from the contrast agent within the transmitted frequency band was used to enhance the scattering from blood. Later, second harmonic components in the nonlinearly scattered signal were used to further enhance the contrast agent signal above the tissue signal in methods generally referred ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B8/00G01S7/52G01S15/89
CPCA61B8/481G01S7/52022G01S7/52026G01S15/8952G01S15/8963
Inventor ANGELSEN, BJORN A.J.HANSEN, RUNE
Owner ANGELSEN BJORN A J
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