Low temperature methods for hermetically sealing reservoir devices

Abstract

Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] Benefit of U.S. Provisional Application No. 60 / 448,123, filed Jul. 17, 2003, is claimed. The application is incorporated herein by reference.BACKGROUND OF THE INVENTION [0002] This invention is generally in the field of methods and structures for hermetically sealing small reservoirs or apertures in devices. [0003] U.S. Pat. No. 5,797,898, No. 6,527,762, No. 6,491,666, and No. 6,551,838 describe devices for the controlled release or exposure of reservoir contents. The devices include a plurality of reservoirs in which the reservoir contents are contained. For example, the reservoirs could contain drug molecules for release or sensors for exposure. In certain embodiments, these reservoirs have openings that must be sealed to isolate the reservoir contents in each reservoir, to prevent leakage of material from or between any of the reservoirs. In many embodiments, hermeticity is desirable, for example to protect the purity or quality of t...

AI Technical Summary

Benefits of technology

[0008] In one aspect, methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. In a preferred embodiment, the reservoir is a micro-reservoir. In a preferred embodiment, the containment device comprises an array of two or more of micro-reservoirs, and the method comprises sealing the two or more micro-reservoirs.

Problems solved by technology

However, the reference neither relates to MEMS devices and hermetic micro-reservoirs nor addresses issues of biocompatibility, device interaction with drug or patient, and control of polymer deposition.

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