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Carotenoid composition and method for protecting skin

a technology of antioxidants and compositions, applied in the direction of biocide, drug compositions, aerosol delivery, etc., can solve the problems of limited use of cathaxanthin, sunburn and skin cancer, and prolonged exposure to sun radiation

Inactive Publication Date: 2005-03-10
LYCORED NATURAL PRODS INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] Further provided by the present invention is the use of a carotenoid composition containing lycopene from a natural source and one or more carotenoid selected from among a group consisting of phytoene and phytofluene as a protective agent against uv light-induced damage to skin. Optionally, said composition may further contain vitamin E.

Problems solved by technology

It is well established that prolonged exposure to sun has damaging effects on the skin.
Particularly, the uv radiation from the sun is known to cause erythema of the skin, sunburn and skin cancer.
However, the use of cathaxanthin is known to be limited due to adverse effects it may have on pigmentation.
The use of such a composition is limited by the negative effect pro-vitamin A carotenoids may have on the subject's health at certain dosage levels.
An excess of vitamin A, which is produced in the body from pro-vitamin A carotenoids, was found to have adverse effects on health.
Stahl et al (“Dietary Tomato Paste Protects against Ultraviolet Light-induced Erythema in Humans”, Biochemical and Molecular Action of Nutrients, Research Communication, (2001) 1449-1451) have shown the protective effect of tomato paste which is known to contain inter alia lycopene, β-carotene and tocopherol, against uv light-induced erythema However, Stahl has reported a problem in achieving desired carotenoid serum levels, suggesting poor bioavailability.

Method used

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  • Carotenoid composition and method for protecting skin

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Carotenoid Composition

[0033] The lycopene used throughout the Examples is natural lycopene by LycoRed®.

[0034] Formulation I: each capsule contains:

[0035] Lycopene 4.88 mg

[0036] Phytoene 0.48 mg

[0037] Phytofluene 0.44 mg

[0038] Vitamin E 1.81 mg

[0039] in soft gel capsules which are prepared according to standard procedures known to the skilled artisan.

[0040] Formulation II: each soft drink bottle contains

[0041] Lycopene 4.1 mg

[0042] Phytoene 2.2 mg

[0043] Phytofluene 1.6 mg

[0044] Vitamin E 3.8 mg

[0045] Formulation III

[0046] Lycopene 5.5 mg

[0047] Vitamin E 2.0 mg

example 2

Comparative Example of Protection against Erythema

[0048] Three treatment groups consumed the following lycopene supplements for 12 weeks:

[0049] a) Group 1—Lyc-O-Mato® soft gel capsules1) (1 capsule twice a day)

[0050] b) Group 2—Lyc-O-Guard™ drink2) (250 ml bottle twice a day)

[0051] c) Group 3—Synthetic lycopene hard shell capsules3) (1 capsule twice a day)

[0052] 1) The carotenoid fraction is a tomato extract containing natural lycopene, phytoene, phytofluene and tocopherols. 2) The carotenoid fraction is a tomato extract similar to Lyc-O-Mato® which is further enriched with phytoene, phytofluene and tocopherols. 3) The carotenoid fraction contains synthetic lycopene and tocopherols.

[0053] The minimal erythema dose (MED), which is the minimal dose of uv radiation which produces a minimal erythema (reddening of the skin) after 24 hours was determined by exposing different small areas of skin to increasing doses of uv radiation. The testing of the effectiveness of the carotenoid ...

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Abstract

A method for protecting skin against damages caused by ultra-violet (uv) radiation from the sun, comprising administering to a subject in need of protection an effective amount of a composition containing lycopene from a natural source and one or more carotenoid selected from among phytoene and phytofluene or mixtures thereof.

Description

FIELD OF THE INVENTION [0001] The present invention relates to the field of protection from sun radiation, particularly to methods and compositions effective in protecting skin. BACKGROUND OF THE INVENTION [0002] It is well established that prolonged exposure to sun has damaging effects on the skin. Particularly, the uv radiation from the sun is known to cause erythema of the skin, sunburn and skin cancer. Protection of the skin from uv radiation can be achieved by protective attire as well as by protection in the form of topical compositions of various protective ingredients. A particular group of protective compositions are intended for oral administration. Oral compositions contain active ingredients which are delivered to the skin via an internal transport mechanism and thus protect the skin from uv radiation damage. A particular group of active ingredients which are suitable for use with said oral compositions are carotenoids. U.S. Pat. No. 3,920,834 describes the use of a mixt...

Claims

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Application Information

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IPC IPC(8): A23L1/30A61K8/02A61K8/97A61K8/11A61K8/31A61K8/67A61K8/92A61K9/06A61K9/16A61K9/20A61K9/48A61K31/01A61K31/355A61P17/16A61Q17/00A61Q17/04C07C
CPCA23L1/3002A23V2002/00A61K8/02A61K8/0216A61K8/11A61K8/31A61Q17/00A61K8/678A23V2250/213A23V2250/712A23L33/105A61P17/16A61P17/18
Inventor ZELKHA, MORRISNIR, ZOHARSEDLOV, TANYA
Owner LYCORED NATURAL PRODS INDS
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