Apparatus for demineralizing osteoinductive bone

a technology of demineralizing bone and osteoinductivity, which is applied in the field of bone graft preparation, can solve the problems of low demineralization rate and inferior osteoinductivity of demineralized bone product, and achieve the effect of demineralizing bon

Inactive Publication Date: 2005-03-17
LIFENET HEALTH
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Benefits of technology

[0005] The present invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus achieves demineraliza

Problems solved by technology

These known methods are problematic in that they require prohibitively long periods of time for processing resulting in a very low demineralization rate, require excessive handling of the ground bone being processed, are capable of proce

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  • Apparatus for demineralizing osteoinductive bone
  • Apparatus for demineralizing osteoinductive bone

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[0014] I. Definitions: The below definitions serve to provide a clear and consistent understanding of the specification and claims, including the scope to be given such terms.

[0015] Acid. By the term “acid” is intended any acid or solutions containing one or more acids, capable of demineralizing bone. For example, suitable acids include highly ionizable acids including, but not limited to, hydrochloric acid, and weakly ionizable acids including, but not limited to, citric acid. Suitable acids include, but are not limited to, organic acids such as formic acid, acetic acid, citric acid, or propionic acid; inorganic acids such as hydrochloric acid or phosphoric acid; physiological tissue-compatible hydroxy carboxylic acids including, but not limited to, citric acid, gluconic acid, malic acid, tartaric acid, fumaric acid, and phosphoric acid; combinations of acids which chelate (bind) calcium and / or amino carboxylic agents including chelators which chelate calcium including, for exampl...

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Abstract

The invention is directed to an apparatus for producing demineralized osteoinductive bone. The apparatus demineralizes bone by subjecting bone, including, for example, ground bone, bone cubes, chips, strips, or essentially intact bone, to either a rapid high volume pulsatile acidification wave process or to a rapid continuous acid demineralization process. The pulsatile acidification wave process includes subjecting bone to two or more rapid pulse/drain cycles in which one or more demineralizing acids is rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel. The continuous acid demineralization process includes subjecting bone to a continuous exchange of demineralizing acid solution in which the demineralizing acid solution is recirculated from the container holding the bone through an ion exchange media. Calcium and phosphate are thereby removed from the bone to produce a regenerated acid, and the regenerated acid is returned to the container holding the bone. Both processes allow bone to be rapidly demineralized to a precise and specific desired residual calcium level without sacrificing osteoinductivity.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of application Ser. No. 10 / 180,989, filed Jun. 26, 2002, which is a continuation-in-part of application Ser. No. 09 / 655,711, filed Sep. 5, 2002, which issued as U.S. Pat. No. 6,534,095 on Mar. 18, 2003, and which claims the benefit of provisional application No. 60 / 152,272, filed Sep. 3, 1999, both of which are herein incorporated by reference.FIELD OF THE INVENTION [0002] The present invention relates to the preparation of bone grafts. The present invention further relates to the demineralization of osteoinductive bone. BACKGROUND OF THE INVENTION [0003] Demineralized freeze-dried bone allograft is widely used in the repair of skeletal defects and periodontal disease. It is known that the implantation of acid demineralized bone in the form of a powder in extraskeletal sites may stimulate new bone formation. Various groups including Syftestad, 1982; Urist et al., 1967; Urist and Strates, 1979; ...

Claims

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Application Information

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IPC IPC(8): A61K35/32
CPCA61L27/3683A61K35/32
Inventor GASKINS, BARTON D.FORD, LOUISMOORE-SMITH, DEBRAO'LEARY, ROBERT K.WILSON, ANNEWOLFINBARGER, LLOYD JR.
Owner LIFENET HEALTH
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