Method for obtaining ozonized oils and vegetable fats and use of said products for pharmaceutical and cosmetic purposes

a technology of ozonized oils and vegetable fats, which is applied in the direction of fatty acid chemical modification, fatty acid oxidation, drug compositions, etc., can solve the problems of low stability of peroxidic products obtained during the process, complex and expensive technologies, and the effect of changing the state of the peroxide produ

Inactive Publication Date: 2006-04-06
CENT NACIONAL DE INVESTIGACIONES CIENTIFICAS (CINC)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This termination criterion of the ozonation has the problem of its change for each type of vegetable oil being ozonized.
Those processes show, as the most important difficulty, the low stability of the peroxidic products obtained during the process.
The attempts for improving that, have caused the use of complex and expensive technologies that have only improved those products in a slight way.
Nevertheless, in the literature reviewed, there is not any reference on the use of ozonized theobroma oil for medical or cosmetic treatments.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Ozonation of Sunflower Oil

[0033] An emulsion composed by 10 liters of oil and 3 liters of distilled water is placed into the bubbling reactor. A 2 m3 / h ozone-oxygen gas flow, with a concentration up to 10% ozone v / v is passed through the oil. The process goes on until the oil reaches the following indicators:—peroxide index (PI) between 600-800 units, —an acid index (AI)—lower than 15 mg / g, concentration of aldehydes—between 0.4-0.9 mmol / g and a viscosity between 100-350 mPa·s. The reactor temperature is kept at 35° C. The product is stored at a temperature between 2 and 8° C.

example 2

Ozonation of theobroma Oil

[0034] The temperature of the bubbling reactor is set at 50° C. by using a thermostat and 10 kg theobroma oil and 3 liters distilled water are introduced into the reactor. A 2 m3 / h ozone—air gas flow with an ozone concentration up to 5% v / v is passed through the oil. The process goes on until the oil reaches a peroxide index (PI) between 1000-1200 units and an acid index (AI) lower than 30 mg / g, The product is stored at a temperature between 2 and 8° C. in inert recipients, until the preparation of the formulations of ovules and therapeutic and / or cosmetic creams is performed.

[0035] B) Examples of the Therapeutic and Cosmetic Utilization of the Ozonized Vegetable Oils

[0036] Ophthalmology

example 3

Application of Ozonized Sunflower Oil for the Treatment of Superficial Keratitis

[0037] A study was carried out in 164 patients with superficial keratitis, over 15 years old, whose diagnosis was made by biomicroscopy. Eighty patients received the ozonized sunflower oil and eighty-four received a conventional treatment. Those patients were randomly distributed and the cure criterion was the disappearance of the symptoms and the visible signs in a slit lamp, using previously sodic fluoresceine. The experimental group received a drop of ozonized sunflower oil three times a day, mydriatics and oral vitamin therapy. The conventional medication administered to the control group was based on mydriatics, iodoxuridine, vitamin therapy and oral anti-inflammatories, such as indomethacine or benzydamine. After 6 days of treatment, 70% from the experimental group were cured, only 11% were cured from the control group. After 30 days of treatment, 98% were cured from the experimental group and 62%...

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Abstract

This invention is linked to the chemical, pharmaceutical and cosmetic industries, where the bactericidal, virucidal, parasiticidal and fungicidal properties of the ozonized vegetable oils and fats are considered. The emulsified vegetable oil or fat is driven to react with ozone in a bubbling reactor, covered by a jacket that makes possible to control the reaction's temperature. Ozone reacts with the double bonds present in vegetable oil or fat, giving rise to the formation of different peroxidic species, responsible for the biological action of those products. The ozonized vegetable oils and fats in those conditions are applied with satisfactory and advanced results to the treatment of diseases in diverse medical specialties, such as ophthalmology, dentistry, dermatology, gastroenterology, gynecology, parasitology, and others. Likewise, the cosmetic application of the ozonized vegetable oil and fats is described, considering their oxygenating and revitalizing properties of the skin. The results of the toxicological studies previously performed show that the products obtained according to this process do not show any cross or adverse reaction.

Description

TECHNICAL FIELD [0001] This invention is according to the A61 K, CO7C and CO9K indexes of the international patents' classification and they are related to a procedure for obtaining ozonized vegetable oils and fats, as well as to the production of ointments for skin care and also to the pharmacological ATC classification, according to the anatomical, therapeutic and chemical systems. This invention consists of a new procedure for obtaining ozonized vegetable oil and fats and their medical and cosmetic applications. TECHNICAL BACKGROUND [0002] The reaction of ozone with the unsaturated compounds has been widely studied (Ozonation in Organic Chemistry, Volumes 1 and 2, Philip S. Bailey, Editors: Alfred T. Blomquist and Harry H. Wasserman, Academic Press, New York, 1978) and the biological activity of the reaction's products has been acknowledged for a long time (U.S. Pat. Nos. 925,590 and 984,722). Two main groups of compounds are remarkable among the ozonized unsaturated compounds fo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/225C07C51/34C07C51/16A61K8/92A61K36/185A61K36/28A61P1/02A61P1/04A61P17/00A61P27/00A61P31/00A61P33/00A61Q11/00A61Q17/00A61Q19/00C11C3/00
CPCA61K8/922A61K36/185A61K36/28A61Q11/00A61Q17/005A61Q19/00C11C3/006A61P1/02A61P1/04A61P17/00A61P27/00A61P31/00A61P33/00
Inventor MIRABAL, JESUS MOLEIROCEPERO, SILVIA AMPARO MENENDEZRUBI, VILFREDO FELIX DIAZGARCIA, LIDIA ASELA FERNANDEZLOZANO, OSCAR ERNESTO LEDEAGOMEZ, MARITZA FELISA DIAZLASTRE, IRENE DE LA MERCEDES LEZCANO
Owner CENT NACIONAL DE INVESTIGACIONES CIENTIFICAS (CINC)
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