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Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces

a tissue surface and physiologic agent technology, applied in the field of drug delivery, to achieve the effect of improving the speed and extent of absorption and distribution of drugs, improving the relief of respiratory and headache symptoms, and improving the speed and extent of drug absorption and distribution

Inactive Publication Date: 2006-04-13
CAPNIA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides methods and systems for delivering physiologically active agents to mucosal surfaces, such as the nasal mucosal surface, oral mucosal surface, ocular mucosal surface, and auricular mucosal surface. The methods involve simultaneously or sequentially delivering the active agent to the mucosal surface while promoting its uptake using an adjuvant gas. The gas can be in the form of a gas, vapor, liquid, mist, or powder, and can be administered through a handheld dispenser or other delivery system. The active agents can include drugs such as nitroglycerin, triptans, imidazopyridines, and opioids. The co-application of the drug and gas can provide faster and more effective relief from symptoms and can reduce the amount of drug required. The patent text also describes the use of adjuvant gases such as carbon dioxide, nitric oxide, and nitrous oxide to enhance the efficacy of the active agents.

Problems solved by technology

While some methods and devices provide for co-delivery of a drug and carbon dioxide or other gases, the purpose is usually not potentiation.

Method used

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  • Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
  • Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces
  • Methods and apparatus for the enhanced delivery of physiologic agents to tissue surfaces

Examples

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Embodiment Construction

[0020] An exemplary carbon dioxide dispenser 100 comprising a carbon dioxide cartridge 101 is illustrated in FIG. 1. The embodiment of FIG. 1 is described in greater detail in parent application Ser. No. 09 / 708,186, now U.S. Pat. No. ______, the full disclosure of which has previously been incorporated herein by reference. A user delivers a dose of carbon dioxide (optionally carrying the physiologically active agent to be delivered) by applying the top of the dispenser 608 to the user's nose or mouth and pushing a button 600 which releases an internal mechanism to allow the CO2 to flow from the top of the dispenser 608. The internal mechanism will lower the pressure of CO2 in the cartridge and will control the flow rate within suitable ranges, typically from 2 to 10 cc / sec. The flow rate may be maintained for a suitable time period, typically at least 2 seconds when suffusing the nasal and sinus passages. The device is cocked by rotation as shown by arrow 602 and pushing the button ...

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Abstract

Apparatus and methods deliver physiologically active agents in the presence of adjuvant gases. The adjuvant gases can enhance the effectiveness of the drug, lower the dosage of drug or concentration of drug necessary to achieve a therapeutic result, or both. Exemplary adjuvant gases include carbon dioxide, nitric oxide, nitrous oxide, and dilute acid gases.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. application Ser. No. 09 / 708,186 (Attorney Docket No. 020017-000310US), filed Nov. 7, 2000 (now U.S. Pat. No. ______), which claimed the benefit of U.S. Provisional Patent Application Nos. 60 / 164,125, filed on Nov. 8, 1999 and 60 / 185,495, filed on Feb. 28, 2000, each of which is incorporated by reference herein.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention relates to drug delivery. More particularly, the present invention relates to methods and apparatus for delivering physiologically active agents to mucosal and other tissue surfaces in the presence of adjuvant gases. [0004] Drug delivery to mucosal surfaces, such as the mucosa of the nose, is well known. While in some cases drugs delivered to the nose and other mucosal surfaces are intended to have local effect, more often such transmucosal drug delivery is intended for systemic administrati...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L9/04A61K9/14A61H33/14A61M11/00A61M11/08A61M15/00A61M37/00
CPCA61H33/14A61H2033/145A61M15/0065A61M15/009A61M37/00A61M2202/0225A61M2202/064A61M2202/0007A61M15/0041A61M11/06A61M15/08A61M15/0081A61K31/137A61K31/21A61K31/4178A61K31/46A61K31/485A61K38/085A61P9/04A61P9/12A61M15/0003A61K47/02A61M13/00
Inventor RASOR, JULIA S.RASOR, NED S.PEREIRA, GERARD F.
Owner CAPNIA INC
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