Aerosol created by directed flow of fluids and devices and methods for producing same

a technology of directed flow and fluids, applied in the direction of combustion types, combustion processes, burners, etc., can solve the problems of disadvantages of pneumatic atomizers, general low efficiency of energy transfer, and more expensive manufacturing

Inactive Publication Date: 2006-08-03
ARADIGM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pneumatic atomizers are disadvantageous relative to non-pneumatic forms of atomization in their need of a source of compressed gas, as well as in their generally higher requirements of energy used to atomize a unit mass of liquid.
This higher energy usage is recognized to be associated with the need to compress gas, but is also associated with a general low efficiency of energy

Method used

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  • Aerosol created by directed flow of fluids and devices and methods for producing same
  • Aerosol created by directed flow of fluids and devices and methods for producing same
  • Aerosol created by directed flow of fluids and devices and methods for producing same

Examples

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examples

[0111] The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the scope of what the inventors regard as their invention nor are they intended to represent that the experiments below are all or the only experiments performed. Efforts have been made to ensure accuracy with respect to numbers used (e.g. amounts, temperature, etc.) but some experimental errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, molecular weight is weight average molecular weight, temperature is in degrees Centigrade.

examples 1-5

[0112]FIGS. 6-12 show results for aerosols produced by methods of the present invention using dry air and dry nitrogen as second fluids 10, and a range of liquids as first fluids 9: distilled water, 2-propanol, 20% (v / v) by volume of ethanol in water (“20% EtOH”), and 0.1% weight in volume (w / v) Polysorbate-20 in distilled de-ionized water (“0.1% Tween”). Tests were performed in four separate experiments with different atomizers. The atomizers were of an axi-symmetric type and had dimensions as specified below in Table A for variables defined in FIGS. 4 and 5. Specifically, the pressure chamber discharge opening was conveniently created by drilling a straight-through hole through a plate of thickness T.

[0113] In experiments 1-4, the droplet size was determined by phase Doppler anemometry (Lefebvre 1989; Bayvel and Orzechowski 1993) along the axis of the aerosol plume a few centimeters downstream from the exit of the atomizer. This measurement technique led to notoriously low rates ...

example 6

[0129]FIGS. 10, 11, and 12 report results from a separate experiment in which the aerosol size distribution was carefully measured as a function of the distance between the first fluid supply means and the pressure chamber, H. Aerosol size distributions were measured outside the atomizer using a standard aerosol measurement technique called laser diffraction (using a Sympatec HELOS system). A device was designed having a configuration as that shown on FIG. 5. The geometric parameters for this system are recorded in the last line of TABLE A above. Measurements of the particle size distribution were made with de-ionized water as first fluid and dry nitrogen as second fluid, at a water flow rate of 35 ml / hr and a pressure in the pressure chamber measured upstream from channel 13 relative to the room into which the aerosol was discharged, of 10 bar. Presented are two statistics that define the particle size: d85 and GSD. d85 represents the diameter under which is represented 85% of the ...

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Abstract

A method of creating small particles by a technology referred to here as “violent focusing” is disclosed, along with devices for generating such violent focusing. In general, the method comprises the steps of forcing a first fluid out of an exit opening of the feeding channel to create a fluid stream. The exit opening is positioned such that the fluid flowing out of the channel flows toward and out of an exit orifice of a pressure chamber which surrounds the exit opening of the feeding channel, and is filled with an atomizing fluid. An atomizing fluid such as a gas is directed towards the first fluid stream in approximately orthogonal directions and surrounding the circumference of the first fluid stream from all sides. The first fluid flow is broken into particles which have dimensions which are smaller than the dimensions of this fluid stream.

Description

CROSS-REFERENCES [0001] This application is a continuation-in-part of application Ser. No. 09 / 591,365 filed Jun. 9, 2000 which claims priority to earlier filed provisional application Ser. No. 60 / 138,698 filed Jun. 11, 1999, which applications are incorporated herein by reference in their entirety.FIELD OF THE INVENTION [0002] This application generally relates to the creation particles created by the directed flow of fluids. BACKGROUND OF THE INVENTION [0003] Devices for creating finely directed streams of fluids and / or creating aerosolized particles of a desired size are used in a wide range of different applications, such as, for example, finely directed streams of ink for ink jet printers, or directed streams of solutions containing biological molecules for the preparation of microarrays. The production of finely dispersed aerosols is also important for (1) aerosolized delivery of drugs to obtain deep even flow of the aerosolized particles into the lungs of patients; (2) aerosol...

Claims

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Application Information

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IPC IPC(8): F23D11/10B05BB05B7/04
CPCA61M11/06B05B1/005B05B7/0408B05B7/0433B05B7/0458B05B7/0475F23D11/104A61M15/0003
Inventor ROSELL, JOANGANAN-CALVO, ALFONSO
Owner ARADIGM
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