Cross-linked polysaccharide composition

a polysaccharide and composition technology, applied in the field of cross-linked polysaccharide compositions, can solve the problems of hyaluronidase, free radicals found in the human body, degraded ha, etc., and achieve the effect of improving degradation characteristics

Inactive Publication Date: 2007-02-01
ULTRACEUTICALS R&D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015] In another embodiment, the present invention provides a cross-linked polysaccharide gel prepared by the process reported herein. The gel may have improved degradation characteristics when administered to a patient.

Problems solved by technology

However, one drawback to administering HA to humans is that HA is degraded by enzymes such as hyaluronidase and free radicals found in the human body.
Furthermore, HA is soluble in water at room temperature, which may also make it less suited to certain applications.

Method used

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Examples

Experimental program
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Synthesis of Cross-Linked Gels

[0064] Separate samples of fibrous [Javenech HTL (MW 1.6-1.33 MD)] and powder hyaluronic acid [Fluka from Streptococcus equi (MW 1.69 MD)] (0.5 g) were each dissolved in 1% NaOH (12.5 ml) with vigorous stirring over a period of 1 hour. 1,4-butanediol diglycidyl ether (BDDE)(12.5 μl) was added with vigorous stirring for 5 minutes and then the resulting solution was incubated without stirring in a water bath at 45° C. for 2 hours. At the end of the incubation period the mixture was removed from the bath, stirred vigorously for 1 minute and then water was removed under high vacuum for 1.5 hours at 35-40° C. The resulting transparent polysaccharide matrices were washed with an isopropyl alcohol and water mixture (IPA / H2O) (6:4, 25 ml) for 22 hours, and then the IPA / H2O mixture was replaced two more times every 22 hours (i.e. for a total wash time of 66 hours). The IPA / H2O mixture was removed, and then 1.3 percent acetic acid in water (25 ml) was added wit...

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Abstract

The present invention provides a process for making cross-linked polysaccharide gels under basic conditions. More particularly, the present invention provides a process for forming cross-linked hyaluronic acid gels under basic conditions. The resulting gels possess improved degradation characteristics, and are useful in a variety of medical and cosmetic applications.

Description

TECHNICAL FIELD [0001] The present invention relates to cross-linked polysaccharide compositions, processes for preparing the compositions, and uses of the compositions in cosmetic, medical and pharmaceutical applications. BACKGROUND ART [0002] Hyaluronic acid (HA) is a member of a class of polymers known as glycosaminoglycans. HA is a long chain linear polysaccharide and is usually present as a sodium salt having the molecular formula (C14H20NNa11)n where n may vary according to the source of the HA and the method of isolating the HA. Molecular weights of HA of up to 14×106 have been reported. [0003] HA and its salts may be isolated from many sources including the human umbilical cord, rooster combs and nearly all connective matrices of vertebrate organisms. HA is also a capsular component of bacteria such as streptococci and may therefore be obtained by fermentation methods such as reported in U.S. Pat. No. 5,411,874 (Fermentech Ltd). [0004] HA is non-immunogenic and therefore has...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14C08G63/91C08G63/48A61K31/738A61P43/00C08B15/00C08B31/00C08B37/08
CPCA61K31/738A61K47/36C08B37/0072A61P17/02A61P19/02A61P37/06A61P43/00C08B37/003C08B37/00
Inventor VONWILLER, SIMONE CHARLOTTEHEBER, GEOFFREY KENNETH
Owner ULTRACEUTICALS R&D
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