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Device with anchoring elements for transdermal delivery or sampling of agents

a technology of transdermal agent and anchoring element, which is applied in the direction of catheters, applications, therapy, etc., can solve the problems of insufficient rate of delivery or flux of polypeptides through the skin to produce a desired therapeutic effect, polypeptides and proteins are easily degraded during the process, and the transdermal delivery of peptides and proteins still faces significant problems

Inactive Publication Date: 2007-05-24
CORMIER MICHEL +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a device for increasing the transdermal delivery of agents such as peptides and proteins through the skin. The device consists of a plurality of microblades that pierce the skin and anchor it more effectively. The microblades are small and can be made with a high degree of reproducibility. The device can be manufactured in high volume production and is low-cost. It minimizes tissue damage and skin irritation. The device can be attached to the skin with minimal effort and can be easily detached. Overall, the invention provides a better and more efficient way to enhance transdermal delivery of agents."

Problems solved by technology

The transdermal delivery of peptides and proteins still faces significant problems.
In many instances, the rate of delivery or flux of polypeptides through the skin is insufficient to produce a desired therapeutic effect due to the binding of the polypeptides to the skin.
In addition, polypeptides and proteins are easily degraded during and after penetration into the skin, prior to reaching target cells.
Likewise, the passive flux of water soluble small molecules such as salts is limited.
Each of these devices provide manufacturing challenges, limited mechanical attachment of the structure to the skin, and / or undesirable irritation of the skin.

Method used

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  • Device with anchoring elements for transdermal delivery or sampling of agents
  • Device with anchoring elements for transdermal delivery or sampling of agents
  • Device with anchoring elements for transdermal delivery or sampling of agents

Examples

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Effect test

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[0083] The effect of the present design was evaluated on the skin resistance of a hairless guinea pig. A microblade array of two square centimeters was applied to ECG electrodes of five square centimeters. The blade array and electrodes were then applied to the skin of the animal. Resistance measurements were taken two minutes after application of the electrode to the skin of the animal. A decrease in resistance was observed indicating that penetration of the blades into the skin had occurred.

[0084] The device was evaluated for its effect on electrotransport flux of a decapeptide in the hairless guinea pig. The following are specifications for the device: the device consisted of a sheet having a plurality of rectangular openings having six blades, three on each long side of a 860 μm by 250 μm rectangle resulting in a 0.22 mm2 open area for each opening. Each set of three blades started at the opposite end of the rectangle as the opposing set of blades. All of the blades were about ...

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Abstract

A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing and anchoring to the skin for increasing transdermal flux of an agent and for improving the attachment of the device to the skin.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] A claim is made, under 35 USC 119(e), to the benefit of the filing of U.S. Patent Application Ser. No. 60 / 019,990 filed Jun. 18, 1996.FIELD OF THE INVENTION [0002] The present invention relates to transdermal agent delivery and sampling. More particularly, this invention relates to the transdermal delivery of agents, such as peptides and proteins, as well as the transdermal sampling of agents, such as glucose, body electrolytes and substances of abuse, such as but not limited to alcohol and illicit drugs. The present invention uses skin-piercing microblades to enhance the transdermal flux of the agents during transdermal delivery or sampling and anchoring elements to assist in retaining the delivery or sampling device in the skin. BACKGROUND OF THE INVENTION [0003] Interest in the percutaneous or transdermal delivery of peptides and proteins to the human body continues to grow with the increasing number of medically useful peptides and ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N1/30A61M31/00A61B5/00B65D81/00A61B5/15A61B5/145A61B5/1473A61B5/157A61B10/00A61B17/20A61M37/00
CPCA61B5/1411A61B5/15142A61B17/205A61M37/0015A61M2037/0007A61M2037/0023A61M2037/0038A61M2037/0046A61M2037/0053A61N1/30A61N1/303A61B5/14514A61B5/150022A61B5/150099A61B5/150282A61B5/150427A61B5/150969A61B5/150984A61B5/15105A61B5/15113A61B10/0045
Inventor CORMIER, MICHELNEUKERMANS, ARMANDBLOCK, BARRYTHEEUWES, FELIXAMKRAUT, ALFRED
Owner CORMIER MICHEL
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