SARS Vaccine Compositions and Methods of Making and Using Them

a composition and vaccine technology, applied in the field of delipidation methods, can solve the problems of severe damage to the body, extreme suffering, morbidity and mortality, and enormous economic burden on society, and achieve the effects of simple, effective and efficient methods, and positive immunologic responses
US20090017069A1Inactive Publication Date: 2009-01-15ELI LILLY & CO +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ELI LILLY & CO
Publication Date
2009-01-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described is a composition and method for reducing the occurrence and severity of infectious diseases, especially infectious diseases such as SARS, in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating immunogenic modified, partially delipidated viral particles with reduced infectivity. The present invention provides delipidated viral vaccine compositions, such as therapeutic vaccine compositions, comprising these modified, partially delipidated viral particles with reduced infectivity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism or, in case of a therapeutic vaccine, to treat or alleviate infection against the lipid-containing infections viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and / or one or more types of virus.
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Description

RELATED APPLICATIONS

[0001] The present application is a continuation-in-part of U.S. non-provisional patent application Ser. No. 11 / 401,434 filed Apr. 10, 2006 which claims the benefit of U.S. provisional patent application Ser. No. 60 / 670,574, filed Apr. 11, 2005, U.S. provisional patent application Ser. No. 60 / 669,738, filed Apr. 8, 2005, and is a continuation-in-part of U.S. non-provisional patent application Ser. No. 10 / 873,015, filed Jun. 21, 2004, which is a continuation in part of U.S. non-provisional patent application Ser. No. 10 / 601,656 filed Jun. 20, 2003, which is a continuation-in-part of U.S. non-provisional patent application Ser. No. 10 / 311,679 filed Dec. 18, 2002, abandoned, which is a U.S. national phase from PCT patent application number PCT / IB01 / 01099 filed Jun. 21, 2001, which claims the benefit of Australian patent application PQ8469 filed Jun. 29, 2000 and PCT patent application number PCT / AU00 / 01603 filed Dec. 28, 2000. The present application also claims the ...

Claims

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