Juxtascleral Drug Delivery and Ocular Implant System

a technology of ocular implants and juxtascleral drugs, which is applied in the field of juxtascleral drug delivery and ocular implant systems, can solve the problems of inability to read, drive, and other detailed tasks, and achieve the effects of reducing the number of patients

Inactive Publication Date: 2009-02-05
ALCON RES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012]In one aspect, the present invention is an ophthalmic drug delivery device having an injector housing, a capsule containing a pharmaceutically agent disposed within the injector housing, a delivery cannula coupled to a distal surface of the injector housing, an injector cannula slidably disposed within the delivery cannula and the injector housi

Problems solved by technology

ARMD attacks the center of vision and blurs it, making reading, driving, and other detailed tasks difficult or impossible.
In wet ARMD, newly formed choroidal blood vessels (choroidal neovascularization (CNV)) leak fluid and cause progressive damage to the retina.
However, photocoagulation can be harmful to the retina and is impractical when the CNV is near the fovea.
Furthermore, over time, photocoagulation often results in recurrent CNV.
However, due to drug-specific metabolic restrictions, systemic administration usually provides sub-therapeutic drug levels to t

Method used

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  • Juxtascleral Drug Delivery and Ocular Implant System
  • Juxtascleral Drug Delivery and Ocular Implant System
  • Juxtascleral Drug Delivery and Ocular Implant System

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Embodiment Construction

[0023]The preferred embodiments of the present invention and their advantages are best understood by referring to FIGS. 1-10 of the drawings, like numerals being used for like and corresponding parts of the various drawings.

[0024]FIGS. 1-2 illustrate various portions of the human eye important to a complete understanding of the present invention. Referring first to FIG. 1, a human eye 90 is schematically illustrated. Eye 90 has a cornea 92, a lens 93, vitreous 95, a sclera 100, a choroid 99, a retina 97, and an optic nerve 96. Eye 90 is generally divided into an anterior segment 89 and a posterior segment 88. Anterior segment 89 of eye 90 generally includes the portions of eye 90 anterior of ora serata 11. Posterior segment 88 of eye 90 generally includes the portions of eye 90 posterior of ora serata 11. Retina 97 is physically attached to choroid 99 in a circumferential manner proximate pars plana 13. Retina 97 has a macula 98 located slightly lateral to optic disk 19. As is well ...

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PUM

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Abstract

Ophthalmic drug delivery devices useful for delivery of pharmaceutically active agents to the posterior segment of the eye are disclosed.

Description

[0001]This application claims the priority of U.S. Provisional Patent Application 60 / 953,054 filed Jul. 31, 2007.FIELD OF THE INVENTION[0002]The present invention generally pertains to instruments for localized delivery of pharmaceutically active agents to body tissue. More particularly, but not by way of limitation, the present invention pertains to instruments for localized delivery of pharmaceutically active agents to the posterior segment of the eye.DESCRIPTION OF THE RELATED ART[0003]Several diseases and conditions of the posterior segment of the eye threaten vision. Age related macular degeneration (ARMD), choroidal neovascularization (CNV), retinopathies (e.g., diabetic retinopathy, vitreoretinopathy), retinitis (e.g., cytomegalovirus (CMV) retinitis), uveitis, macular edema, glaucoma, and neuropathies are several examples.[0004]Age related macular degeneration (ARMD) is the leading cause of blindness in the elderly. ARMD attacks the center of vision and blurs it, making read...

Claims

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Application Information

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IPC IPC(8): A61F9/00A61F2/14A61M31/00A61M37/00
CPCA61F9/0017
Inventor CAZZINI, KARL
Owner ALCON RES LTD
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