Neurofibromin pathway modulators

a neurofibromatosis and pathway technology, applied in the field of neurofibromatosis treatment methods, can solve the problems of poor 5-year survival rate, precocious puberty or other neurological abnormalities, and inability to effectively treat the diseas
US20090208953A1Active Publication Date: 2009-08-20WASHINGTON UNIV IN SAINT LOUIS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
WASHINGTON UNIV IN SAINT LOUIS
Publication Date
2009-08-20

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Abstract

The present invention encompasses methods for treating neurofibromatosis and methods for screening for modulators of the neurofibromin pathway.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the priority of U.S. provisional application No. 60 / 987,156, filed Nov. 12, 2007, which is hereby incorporated by reference in its entirety.GOVERNMENTAL RIGHTS

[0002] This invention was made in part with Government support under Grant Number DAMD-17-03-1-0215 awarded by The Department of Defense and Grant Number U01-CA84314 awarded by the National Cancer Institute. The Government may have certain rights in this invention.FIELD OF THE INVENTION

[0003] The present invention relates to methods for treating neurofibromatosis and to methods for screening for modulators of the neurofibromin pathway.BACKGROUND OF THE INVENTION

[0004] NF1 is a common autosomal dominant disorder that affects approximately 1:3000 people worldwide (over 100,000 individuals in the United States alone) and predisposes to the development of both benign and malignant tumors, including optic glioma and malignant peripheral nerve sheath tumor (MPNST). Op...

Claims

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