Stabilized insulin-like growth factor polypeptides

a growth factor and polypeptide technology, applied in the direction of peptide/protein ingredients, extracellular fluid disorder, metabolism disorder, etc., can solve the problems that igf-1 and igf-2 appear to be poor drug candidates, and achieve the effect of avoiding or reducing this cleavag
US20100173839A1Inactive Publication Date: 2010-07-08NOVARTIS AG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NOVARTIS AG
Publication Date
2010-07-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to stabilized polypeptides having an IGF-1 or IGF-2 sequence and an E-peptide sequence, where the natural physiological cleavage of the E-peptide from the IGF is prevented.
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Description

BACKGROUND OF THE INVENTION

[0001] Insulin-like growth factors (IGFs) are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the insulin-like growth factor axis) consists of two cell-surface receptors (IGF-1R and IGF-2R), two ligands (IGF-1 and IGF-2), a family of six high-affinity IGF-binding proteins (IGFBP 1-6), and associated IGFBP degrading enzymes (proteases). This system is important not only for the regulation of normal physiology but also for a number of pathological states (Glass, Nat Cell Biol 5:87-90, 2003).

[0002] The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death (apoptosis). IGF-1 is mainly secreted by the liver as a result of stimulation by human growth hormone (hGH). Almost every cell in the human body is affected by IGF-1, especially cells in muscles, cartilage, bones, liver, kidney, nerves, skin and lungs. In addition to the ...

Claims

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