14-3-3 Antagonists for the Prevention and Treatment of Arthritis

a technology of 1433 proteins and antagonists, applied in the field of arthritis prevention and treatment, can solve the problems of permanent structural damage, swelling of the joint area, and substantial loss of mobility, and achieve the effect of reducing the effectors of arthritis
US20110027269A1Inactive Publication Date: 2011-02-03THE UNVERSITY OF BRITISH OFFICE
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THE UNVERSITY OF BRITISH OFFICE
Publication Date
2011-02-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and / or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14-3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical composition and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60 / 990,520, filed 27 Nov. 2007, and U.S. Provisional Patent Application Ser. No. 61 / 077,123, filed 30 Jun. 2008, which are expressly incorporated herein in their entirety by reference.FIELD OF THE INVENTION

[0002] The invention relates to the involvement of 14-3-3 proteins in arthritis, and compositions and methods for the prevention and treatment of arthritis.BACKGROUND OF THE INVENTION

[0003] Arthritis, or arthralgia, generally refers to inflammatory disorders of the joints of the body, and is usually accompanied by pain, swelling and stiffness. Arthritis may result from any of several causes including infection, trauma, degenerative disorders, metabolic disorders or disturbances or other unknown etiologies. Osteoarthritis (OA) is a common form of arthritis that may occur following trauma to a joint, following an infection of a joint or simply as a result of...

Claims

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