Method and device for monitoring and improving arteriogenesis
a technology for arteriogenesis and sensing devices, which is applied in the field of devices and methods for sensing the arteriogenic capacity of patients, can solve the problems of not leading to satisfactory, reliable training increases, and not leading to significant and reliable measures of arteriogenic capacity, so as to reduce symptoms of ischemia, increase blood pressure, and increase the slew rate
Inactive Publication Date: 2012-03-08
BUSCHMANN IVO RAINER +1
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However, these approaches focused on training the particular vessel section by increasing the shear stress on the vessel have not led to satisfactory results.
In other words, stimulating the arteriogenesis by training with high shear stresses has not resulted in reliable training increases.
In addition, taking the shear stress as a measure for determining the training performance according to the prior art approaches has not led to a significant and reliable measure for the arteriogenic capacity.
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. Introduction
[0065]Arterial and venous vascular networks show a distinct genetic signature, function and branching architecture (De Smet et al., 2009; Swift and Weinstein, 2009). Specification of arterial-venous vessel identity and formation of branched vascular networks occur during early embryogenesis and are modulated by hemodynamic factors (Jones et al., 2004; le Noble et al., 2004; Lucitti et al., 2007), but the precise mechanisms are unclear. Circulation of blood creates mechanical forces in vessels (Garcia-Cardena et al., 2001; Jones et al., 2006), and affects oxygenation of developing organs. Here we investigated which mechanical forces, or secondary factors including oxygenation of the blood (Fraisl et al., 2009), might be relevant for regulating vessel identity in developing embryonic vascular networks in vivo. We furthermore assessed the morphological and genetic changes occurring in the embryonic yolk sac vasculature in response to manipulations of hemodynamic condition...
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A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined. An external pressure is applied repeatedly to the arteriovascular section in synchronization with the occurrence of the determined maximum.
Description
TECHNICAL FIELD[0001]The present invention relates to devices and methods for sensing the arteriogenic capacity of a patient. The arteriogenic capacity reflects the increase of diameter and / or elastic properties of arterial vessels. In case of pathological properties of particular artery sections, respective treatments are focused on improving these properties by arteriogenesis.[0002]In order to stimulate arteriogenesis improving an arteriovascular condition in an arteriovascular section of a patient prior art approaches are focused on the shear stress of artery vessels generated by the blood flow in the vessel. Studies pertaining to the prior art have suggested to increase the shear stress for training the vessels in pathologic vessel sections for training the vessel section. However, these approaches focused on training the particular vessel section by increasing the shear stress on the vessel have not led to satisfactory results. In other words, stimulating the arteriogenesis by ...
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IPC IPC(8): A61B5/026A61B8/06A61B5/055A61B5/053A61B5/022A61B5/0295A61B5/0215A61B6/00A61B5/021
CPCA61B5/02007A61M1/107A61B5/026A61M2205/3334A61B5/4836A61B5/0036A61M60/274A61M60/531A61B5/0215A61B5/02241A61B5/0261A61B5/0263A61B5/0265A61B5/0295A61B8/06
Inventor BUSCHMANN, IVOPRIES, AXELLENOBLE, FERDINAND
Owner BUSCHMANN IVO RAINER
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