Unsaturated nitrogen heterocyclic compounds useful as pde10 inhibitors

a technology of unsaturated nitrogen and heterocyclic compounds, applied in the field of unsaturated nitrogen heterocyclic compounds, can solve the problem that a large amount of information cannot be obtained by other means
US20140213572A1Inactive Publication Date: 2014-07-31INC AMGEN
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INC AMGEN
Publication Date
2014-07-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

Unsaturated nitrogen heterocyclic compounds of formula (I):as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation application of U.S. application Ser. No. 13 / 105,860, filed May 11, 2011, which claims the benefit of U.S. Provisional Application No. 61 / 334,525, filed May 13, 2010, which are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] Provided herein are certain unsaturated nitrogen heterocyclic compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.BACKGROUND

[0003] Neurotransmitters and hormones, as well as other types of extracellular signals such as light and odors, create intracellular signals by altering the amounts of cyclic nucleotide monophosphates (cAMP...

Claims

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