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Methods of manufacturing bioactive gels from extracellular matrix material

a bioactive gel and extracellular matrix technology, applied in the direction of peptide/protein ingredients, drug compositions, prosthesis, etc., can solve the problems of additional regulatory barriers to marketing, degradation of gel bioactivity, etc., and achieve the effects of reducing the number of purification steps

Inactive Publication Date: 2014-08-14
ACELL INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0008]The advantages provided by the methods of manufacturing bioactive gels in the above manner are that aggressive purification steps, which are deleterious to bioactivity, tedious to perform or are time consuming, are avoided.

Problems solved by technology

Although uses of ECM as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction are very promising, challenges remain in the process to manufacture bioactive gels from ECM, which retain their bioactivity.
The process of manufacturing bioactive gels from ECM described thus far require the use of enzymes and are time consuming because they require aggressive purification steps, which may lead to depletion in the bioactivity of the gels and may present additional regulatory barriers to marketing.

Method used

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Embodiment Construction

[0011]The present invention is directed to methods of manufacturing bioactive gels from ECM, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. As will be described in detail below, these manufacturing methods take advantage of a new recognition that bioactive gels from ECM can be created by treating a particularized ECM in a basic environment, which when neutralized with acid provides bioactive gels.

[0012]In accordance with the inventive methods, the ECM may be derived from native mammalian tissues including but not limited to submucosa, dermis, epithelial basement membrane, aponeurosis, fascia, tendon, ligament, smooth and skeletal muscle and treatment site-specific ECM. The native mammalian tissue source may be porcine, bovine, ovine, allogenic, or autogenic, for example. For example, the ECM may be SIS (small intestinal submucosa), UBS (urinary bladder subm...

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Abstract

The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.

Description

GOVERNMENT SUPPORT[0001]This invention was supported by grant no. NCC 9-58 from the National Space Biomedical Research Institute through NASA. The Government has certain rights in the invention.TECHNICAL FIELD OF THE INVENTION[0002]The present invention is related to methods of manufacturing bioactive gels from extracellular matrix material and their uses for restoration of tissues in a patient.BACKGROUND[0003]Biologic scaffolds composed of extracellular matrix material (ECM) have been used for the repair of variety of tissues including the lower urinary tract, esophagus, myocardium and musculotendinous tissues, often leading to tissue-specific constructive remodeling with minimal or no scar tissue formation.[0004]Although uses of ECM as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction are very promising, challenges remain in the process to manufacture bioactive gels from ECM, which retain their bioactivity.[0005...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/22A61K9/00
CPCA61K35/22A61L27/3683A61K38/1866A61L27/3633A61K9/0024A61L27/54A61L27/3687A61K38/1825A61K35/12A61K38/18A61L27/52A61L2300/414A61K38/00A61P17/02A61L27/22A61L27/3691A61L27/50A61L2300/252A61L2300/412
Inventor KENTNER, KIMBERLY A.STUART, KATHERINE A.JANIS, ABRAM D.
Owner ACELL INC
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