System and method for optogenetic therapy

a technology of optogenetic therapy and optogenetic therapy, applied in the field of optogenetic therapy, can solve the problems of significant clinical downsides and inhibit such signals, and achieve the effect of improving the engagement of the targeted tissue structur
US20150202456A1Inactive Publication Date: 2015-07-23CIRCUIT THERAPEUTICS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CIRCUIT THERAPEUTICS
Publication Date
2015-07-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
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Description

RELATED APPLICATION DATA

[0001] This is a continuation application of International Application No. PCT / US2013 / 000262, filed on Nov. 21, 2013, which claims priority to U.S. Provisional Application Ser. No. 61 / 729,283, filed on Nov. 21, 2012. The foregoing applications are hereby incorporated by reference into the present application in their entirety. Priority to the aforementioned applications is hereby expressly claimed in accordance with 35 U.S.C. §§119, 120, and 365 and any other applicable statutes.INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ELECTRONICALLY

[0002] Incorporated by reference in its entirety is a computer-readable nucleotide / amino acid sequence listing submitted concurrently herewith, and identified as follows: One 122 KiloByte ASCII (Text) file named “14—444—770_SeqList_ST25.txt” created on Mar. 12, 2015.FIELD OF THE INVENTION

[0003] The present invention relates generally to systems, devices, and processes for facilitating various levels of control over cells and ...

Claims

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