Beta-3 adrenoceptor agonists for the treatment of pulmonary hypertension

a pulmonary hypertension and beta-3 technology, applied in the field of medicine, can solve the problems of lack of ph treatment, high incidence of ph in the population, and high morbidity and mortality, and achieve the effects of reducing pulmonary pressure, favorable response, and beneficial effect of ph

Active Publication Date: 2015-12-31
HOSPITAL CLINIC DE BARCELONA +1
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]The authors of the present invention have satisfactorily found that selective stimulation of beta-3 adrenergic receptors has a beneficial effect in the pulmonary hypertension (PH). It has therefore been observed that the administration of selective beta-3 adrenergic receptor agonists in chronic PH and acute PH models elicits a favorable response to said disease: reduction of p

Problems solved by technology

The incidence of PH in the population is high and it is associated with high morbidity and mortality.
Currently, there is a lack of treatments for PH.
In addition, these treatments

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Beta-3 adrenoceptor agonists for the treatment of pulmonary hypertension
  • Beta-3 adrenoceptor agonists for the treatment of pulmonary hypertension
  • Beta-3 adrenoceptor agonists for the treatment of pulmonary hypertension

Examples

Experimental program
Comparison scheme
Effect test

examples

Methods

Generating the Experimental Models

Acute PH:

[0087]In 10 2 month old healthy pigs (weighing ≈30 kg) anesthetized, intubated and ventilated with 40% FiO2, while continuously monitoring blood pressure, heart rate (HR), oxygen saturation as well as PAP and repeated measurements of cardiac output (CO) by means of thermodilution using a Swan-Ganz catheter, acute PH was generated by means of pulmonary embolization with a suspension of microspheres (Sephadex G50 coarse; Pharmacia Biotech; Freiburg, Germany) by femoral vein route. The dose necessary for causing an increase of mean PAP≧40 mmHg to remain stable for 10 minutes was administered. At that time the animals were randomized to receive specific β3 agonist BRL37344 (5 μg / Kg) or physiological saline (vehicle).

Chronic PH:

[0088]For the purpose of reproducing a broad spectrum of PH in the general population, 2 experimental models of chronic PH were developed: a pre-capillary model which would represent clinical groups 1, 3, 4 and 5; ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Currentaaaaaaaaaa
Currentaaaaaaaaaa
Selectivityaaaaaaaaaa
Login to view more

Abstract

The invention relates to the use of selective agonists of beta-3 adrenergic receptors for the treatment and/or prevention of pulmonary hypertension.

Description

FIELD OF THE INVENTION[0001]The present invention is comprised within the field of medicine, more particularly, it relates to treating pulmonary hypertension.BACKGROUND OF THE INVENTION[0002]Pulmonary hypertension (PH), defined as the increase of mean pulmonary artery pressure (PAP) above normal values, encompasses a series of diseases characterized by the increase of pulmonary vascular resistances (PVRs) and progressive deterioration of the right ventricle (RV) function (McLaughlin 2009). In this regard, most studies refer to PH for mean PAP values above 25 mmHg, considering that a typical mean PAP in humans is about 12 to 15 mmHg.[0003]There are many causes of PH which have been classified into 5 groups: pulmonary arterial hypertension (PAH); PH due to left heart disease; PH due to lung disease; chronic thromboembolic PH; and PH of an unknown or multifactorial origin. Unlike other groups, PH due to left heart disease is of a post-capillary origin, characterized by the increase of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/216A61K31/426
CPCA61K31/195A61K2300/00A61K31/216A61K31/36A61K31/426A61K31/4412A61K31/55A61K31/5517A61K31/63A61P11/00A61P43/00A61P9/00A61P9/12A61K31/135
Inventor IBÁÑEZ CABEZA, BORJAGARCÍA ÁLVAREZ, ANAFUSTER CARULLA, VALENTÍN
Owner HOSPITAL CLINIC DE BARCELONA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap