System and method for optogenetic therapy

Abstract

Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

Description

RELATED APPLICATION DATA[0001]This is a continuation application of International Application No. PCT / US2013 / 000262, filed on Nov. 21, 2013, which claims priority to U.S. Provisional Application Ser. No. 61 / 729,283, filed on Nov. 21, 2012. The foregoing applications are hereby incorporated by reference into the present application in their entirety. Priority to the aforementioned applications is hereby expressly claimed in accordance with 35 U.S.C. §§119, 120, and 365 and any other applicable statutes.INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ELECTRONICALLY[0002]Incorporated by reference in its entirety is a computer-readable nucleotide / amino acid sequence listing submitted concurrently herewith, and identified as follows: One 122 KiloByte ASCII (Text) file named “14—449—096_SeqList_ST25.txt” created on Mar. 13, 2015.FIELD OF THE INVENTION[0003]The present invention relates generally to systems, devices, and processes for facilitating various levels of control over cells and ...

AI Technical Summary

Benefits of technology

The patent is about an implantable device that can distribute light to a specific tissue structure in the body. The device has a slab-like structure that receives light from a light source and directs it towards the targeted tissue structure. The slab-like structure has an inner surface that contacts the tissue structure and an outer surface that reflects some of the light back towards the tissue structure. This reflective element can help to improve the amount of light that reaches the targeted tissue structure. The device may have a smooth inner surface and may be made of materials like water, air, oil, polymers, or nanoparticle-containing polymers. The device can be designed to interface with multiple tissue structures and may have different output spectra for each tissue structure. Overall, this technology can help to improve the effectiveness of light therapy for certain medical applications.

Problems solved by technology

Electrical stimulation techniques, on the other hand, may be more precise from an interventional time scale perspective, but they generally are not cell type specific and may therefore involve significant clinical downsides.

Conversely, membrane hyperpolarization leads to the inhibition of such signals.

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