Treating and preventing disease with tma and tmao lowering agents

US20160089386A1Inactive Publication Date: 2016-03-31THE CLEVELAND CLINIC FOUND
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THE CLEVELAND CLINIC FOUND
Publication Date
2016-03-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided herein are compositions, systems, and methods for treating a disease, such as kidney disease, with an agent that reduces the production of trimethylamine (TMA) or trimethylamine-n-oxide (TMAO) in a subject. In certain embodiments, the agent is: i) 3,3-dimethyl-1-butanol (DMB) or a DMB derivative or related compound, ii) acetylsalicylic acid or derivative thereof (e.g., with an enteric coating for delivery to the colon and / or cecum); iii) a flavin monooxygenase 3 (FMO3) inhibitor; iv) a gut TMA lyase inhibitor; v) an antibiotic or antimicrobial; vi) a probiotic or prebiotic; vii) an antiplatelet agent; or viii) a TMA and / or TMAO sequestering agent.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present invention claims priority to U.S. Provisional Patent Application 62 / 056,168, filed Sep. 26, 2014, which is incorporated by reference in its entirety.FIELD OF THE INVENTION

[0002] Provided herein are compositions, systems, and methods for treating a disease, such as kidney disease, with an agent that reduces the production of trimethylamine (TMA) or trimethylamine-n-oxide (TMAO) in a subject. In certain embodiments, the agent is: i) 3,3-dimethyl-1-butanol (DMB) or a DMB derivative or related compound, ii) acetylsalicylic acid or derivative thereof (e.g., with an enteric coating for delivery to the colon and / or cecum); iii) a flavin monooxygenase 3 (FMO3) inhibitor; iv) a gut TMA lyase inhibitor; v) an antibiotic or antimicrobial; vi) a probiotic or prebiotic; vii) an antiplatelet agent, or vii) a TMA and / or TMAO sequestering agent.BACKGROUND

[0003] Kidneys of the human body function to remove excess fluids as well as some ions. The...

Claims

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